B4DUC8 · B4DUC8_HUMAN
- ProteinS-methyl-5'-thioadenosine phosphorylase
- GeneMTAP
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids300 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Catalytic activity
- phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 35 | phosphate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 77-78 | phosphate (UniProtKB | ChEBI) | ||||
Sequence: RH | ||||||
Binding site | 110-111 | phosphate (UniProtKB | ChEBI) | ||||
Sequence: TA | ||||||
Site | 195 | Important for substrate specificity | ||||
Sequence: S | ||||||
Binding site | 213 | substrate | ||||
Sequence: M | ||||||
Binding site | 214 | phosphate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 237-239 | substrate | ||||
Sequence: DYD | ||||||
Site | 250 | Important for substrate specificity | ||||
Sequence: V |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Molecular Function | S-methyl-5-thioadenosine phosphorylase activity | |
Biological Process | L-methionine salvage from methylthioadenosine | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameS-methyl-5'-thioadenosine phosphorylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB4DUC8
Proteomes
Organism-specific databases
Disease & Variants
Variants
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The viewer provides 399 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
Expression
Gene expression databases
Interaction
Subunit
Homotrimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 28-272 | Nucleoside phosphorylase | ||||
Sequence: RIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTI |
Sequence similarities
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length300
- Mass (Da)33,186
- Last updated2008-09-23 v1
- Checksum2D6BC03E36B1D975
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q13126 | MTAP_HUMAN | MTAP | 283 | ||
J3KRN1 | J3KRN1_HUMAN | MTAP | 112 | ||
A0A2R8Y4K0 | A0A2R8Y4K0_HUMAN | MTAP | 55 | ||
F8WES2 | F8WES2_HUMAN | MTAP | 50 | ||
J3QSB7 | J3QSB7_HUMAN | MTAP | 242 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL359922 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL449423 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AK300592 EMBL· GenBank· DDBJ | BAG62290.1 EMBL· GenBank· DDBJ | mRNA |