DNA analysis of benign adult familial myoclonic epilepsy reveals associations between the pathogenic TTTCA repeat insertion in SAMD12 and the nonpathogenic TTTTA repeat expansion in TNRC6A.
we report the important roles of GW182 and DDX6 but not Dicer Ago2 and DCP1A in PB formation and that Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection reduces PB formation through several specific interactions with viral RNA-binding protein ORF57
Besides the role of GW182 as part of repressor complexes inside the cell they function in wide variety of cellular processes including pathogenesis circadian rhythm and cell cycle. (Review)
Study results demonstrate that TNRC6A regulates the biogenesis of the circRNA circ0006916 which regulates lung cancer cells proliferation by binding to miR-522-3p and inhibiting PHLPP1 activity.
that the interactions observed between TNRC6A and importin-alpha are conserved between mouse and human complexes. Our results highlight the ability of monopartite cNLS sequences to maximise contacts at the importin-alpha major binding site as well as regions outside the main binding cavities
In miRNA-mediated gene silencing the physical interaction between human Argonaute (hAgo) and GW182 (hGW182) is essential for facilitating the downstream silencing of the targeted mRNA. hGW182 can recruit up to three copies of hAgo via its three GW motifs. This may explain the observed cooperativity in miRNA-mediated gene silencing.
The results suggest that overexpressed Dcp1a and GW182 can form different cytoplasmic aggregates and play distinct biological roles in the miRNA pathway.
miRNAs AGOs GW182 the CCR4-NOT complex and DDX6/Me31B repress and degrade polyadenylated mRNA targets that are translated via scanning-independent mechanisms in both human and Drosophila melanogaster cells
28.6% of patients containing autoantibodies to the trinucleotide repeat region of the TNRC6A were shown to have a single nucleotide polymorphism at c.344C>A in the CAG/CCA/G-rich region of TNRC6A.
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