B4DSN5 · B4DSN5_HUMAN

  • Protein
    Tyrosine-protein phosphatase non-receptor type
  • Gene
    PTPN1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Catalytic activity

Features

Showing features for binding site, active site.

136250100150200250300350
TypeIDPosition(s)Description
Binding site108substrate
Active site142Phosphocysteine intermediate
Binding site142-148substrate
Binding site189substrate

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Molecular Functionprotein tyrosine phosphatase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein phosphatase non-receptor type
  • EC number

Gene names

    • Name
      PTPN1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B4DSN5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane336-357Helical

Keywords

Disease & Variants

Variants

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The viewer provides 343 variants from UniProt as well as other sources including ClinVar and dbSNP.

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Organism-specific databases

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)130PRIDEPhosphoserine
Modified residue (large scale data)132PRIDEPhosphoserine
Modified residue (large scale data)143PRIDEPhosphoserine
Modified residue (large scale data)222PRIDEPhosphoserine
Modified residue (large scale data)265PRIDEPhosphothreonine
Modified residue (large scale data)279PRIDEPhosphoserine
Modified residue (large scale data)290PRIDEPhosphoserine
Modified residue (large scale data)292PRIDEPhosphoserine
Modified residue (large scale data)295PRIDEPhosphothreonine
Modified residue (large scale data)305PRIDEPhosphoserine
Modified residue (large scale data)313PRIDEPhosphoserine

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain1-204Tyrosine-protein phosphatase
Domain116-195Tyrosine specific protein phosphatases
Region265-286Disordered
Region305-325Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    362
  • Mass (Da)
    41,260
  • Last updated
    2008-09-23 v1
  • Checksum
    C4611A4F5A4B5982
MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
P18031PTN1_HUMANPTPN1435

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL034429
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL133230
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF456940
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AK299830
EMBL· GenBank· DDBJ
BAG61697.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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