These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43 truncations and mutations affect its function in tau exon 10 splicing possibly because of TDP-43 mislocalization to the cytoplasm.
results show that neuroinflammation promotes neuronal autophagy and that chronic mild TLR4 stimulation attenuates Alzheimer's disease-related tauopathy likely by activating neuronal autophagy
Exogenous progestorone (9300-93 000 pg/ml) had a significant effect on overall Tau and nuclear TDP-43 levels reducing total Tau levels by approximately 1.5-fold and increasing nuclear TDP-43 by 1.7- to 2.0-fold.
we report mixed tau and TDP-43 pathology in a woman with behavioural variant frontotemporal lobar degeneration who had the C9ORF72 mutation and the p.Ala239Thr variant in MAPT gene not previously associated with tau pathology
Hyperphosphorylation of Tau induced by naturally secreted amyloid-beta at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3beta signaling pathway.
Associated with NEUROLOGICAL: Parkinson's disease., Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
In univariate analyses Tau- and ER-positive status were both associated with better DFS and OS whereas greater tumor size high grade lymph node- and HER2-positive status were each associated with worse DFS and OS.
This study found that modest Modest associations (uncorrected P < 0.05) were observed for common variants around MAPT in Australia patient with Parkinson's disease; Observational study of gene-disease association. (HuGE Navigator)
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