It analyses revealed that Trak1 interacts and colocalizes with mitofusins on the outer mitochondrial membrane and functions with mitofusins to promote mitochondrial tethering and fusion.
Mitofilin-knockdown cells showed decreased mitochondrial membrane potential (DeltaPsim) and intracellular ATP content which were minimally affected in CHCHD6-knockout cells.
Mic60 interacted with mtDNA and was involved in the architecture of mtDNA D-loop region. Taken together our findings reveal a previously unrecognized important role of Mic60 in mtDNA transcription.
role in protein import related to maintenance of mitochondrial structure is suggested; mitofilin helps regulate mitochondrial morphology and four of the associated proteins (metaxins 1 and 2 SAM50 and CHCHD3) have been implicated in protein import
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