N6-methyladenosine reader YTH N6-methyladenosine RNA binding protein 3 or insulin like growth factor 2 mRNA binding protein 2 knockdown protects human bronchial epithelial cells from hypoxia/reoxygenation injury by inactivating p38 MAPK AKT ERK1/2 and NF-kappaB pathways.
Abundance of N-6-methyladenosine and expression of VIRMA/YTHDF3 were different among testicular germ cell tumors subtypes with higher levels in seminomas (SEs) suggesting a contribution to SE phenotype maintenance.
These results indicate that together with YTHDF1 and YTHDF2 YTHDF3 plays critical roles to accelerate metabolism of N(6)-methyladenosine -modified mRNAs in the cytoplasm.
The authors found that the overexpression of YTHDF proteins in cells inhibited HIV-1 infection mainly by decreasing HIV-1 reverse transcription while knockdown of YTHDF1-3 in cells had the opposite effects. Moreover silencing the N(6)-methyladenosine writers decreased HIV-1 Gag protein expression in virus-producing cells while silencing the N(6)-methyladenosine erasers increased Gag expression.
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