Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5' Untranslated Region.
Study provides a panoramic view of enhancer RNAs (eRNAs) transcription and categorization of eRNAs. Master transcription factor MyoD is crucial in activating eRNA production. Super enhancer (se) generated seRNA-1 and -2 promote myogenic differentiation in vitro and in vivo by binding to heterogeneous nuclear ribonucleoprotein L (hnRNPL).
Knockdown of heterogeneous nuclear ribonucleoprotein L (hnRNP L) sensitizes the human U937 monocytic cells under hypoxia stress but not in normoxia via inducing cell apoptosis partially due to the reduced translation of hnRNP L target mRNAs.
CASC9:HNRNPL complex is a clinically relevant viability-associated lncRNA/protein complex which affects AKT signaling and DNA damage sensing in hepatocellular carcinoma.
IRF1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately regulate CEACAM1 transcription alternative splicing and translation and may significantly contribute to CEACAM1 silencing in cancer.
The data demonstrate that the hnRNP L and its paralog LL differentially control hormone gene expression programs at multiple levels and hnRNP L in particular is critical for protecting the transcriptome from aberrant usage of intronic sequences.
Translation of VEGFA mRNA in myeloid cells is dictated by a bi-directional interaction between miR-574-3p a CA-rich microRNA and hnRNP L. In normoxia miR-574-3p acting as a decoy binds cytoplasmic hnRNP L and prevents its binding to the CARE and stimulation of VEGFA mRNA translation simultaneously permitting miR-297-mediated translational silencing.
hnRNP-L contributes to poor prognosis and tumor progression of BC by inhibiting the intrinsic apoptotic signaling and enhancing MAPK signaling pathways
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