B4DP64 · B4DP64_HUMAN

  • Protein
    Acyl-protein thioesterase 1
  • Gene
    LYPLA1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentnuclear membrane
Cellular Componentplasma membrane
Molecular Functionhydrolase activity

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Acyl-protein thioesterase 1
  • EC number
  • Alternative names
    • Lysophospholipase 1
    • Lysophospholipase I
    • Palmitoyl-protein hydrolase

Gene names

    • Name
      LYPLA1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B4DP64

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

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The viewer provides 46 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-122Phospholipase/carboxylesterase/thioesterase
Domain127-191Phospholipase/carboxylesterase/thioesterase

Sequence similarities

Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    196
  • Mass (Da)
    21,123
  • Last updated
    2008-09-23 v1
  • Checksum
    92A418FDEE32A5F4
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
O75608LYPA1_HUMANLYPLA1230
A0A087X1K9A0A087X1K9_HUMANLYPLA1166
E5RJ48E5RJ48_HUMANLYPLA190
E5RFT6E5RFT6_HUMANLYPLA158
E5RGR0E5RGR0_HUMANLYPLA1197
E5RI35E5RI35_HUMANLYPLA1103

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC100821
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AK298206
EMBL· GenBank· DDBJ
BAG60476.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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