DDX39B promotes proliferation and colony forming potential of cells and its levels are significantly elevated in diverse cancer types.DDX39B regulates the pre-ribosomal RNA levels.
Study showed that a genetic variant in the 5' UTR of DDX39B reduces translation of DDX39B mRNAs and increases multiple sclerosis (MS) risk. Importantly this DDX39B variant showed strong genetic & functional epistasis with allelic variants in IL7R exon 6; study establishes the occurrence of biological epistasis in humans & provides mechanistic insight into the regulation of IL7R exon 6 splicing & its impact on MS risk.
Distinct features of RNA influence and ATPase efficiency between UAP56 and TcSub2 may reflect distinct structures for functional sites of TcSub2. For this reason ligand-based or structure-based methodologies can be applied to investigate the potential of TcSub2 as a target for new drugs.
However no significant association was observed between the DDX39B -22 G/C polymorphism in the cases and controls. Furthermore it is clarified that the protective effect of IL-4 -590 is independent from APOE protective genotypes
The G allele of DDX39B-22C > G was associated with absent or decreased manifestations of vivax malaria and the C allele was a risk factor for disease complications.
We unravel the role of unexplored immunologically important genes BAT1 and BTNL2 and the haplotypes of the significantly associated SNPs therein to understand susceptibility to the disease leprosy and its differential severity.
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