Myofibrillogenesis Regulator-1 Regulates the Ubiquitin Lysosomal Pathway of Notch3 Intracellular Domain Through E3 Ubiquitin-Protein Ligase Itchy Homolog in the Metastasis of Non-Small Cell Lung Cancer.
The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6 Survivin and SERCA2a.
review summarizes the biogenesis characteristics and functions of circRNAs as well as recent progression regarding the biological functions and potential molecular mechanisms of circ-ITCH and future challenges in cancer research
Circ-ITCH is downregulated in prostate cancer tissues and its low expression correlates with advanced pathologic T stage high lymph mode metastasis risk and poor survival in prostate cancer patients underwent radical prostatectomy.
Study defined ITCH as a direct and functional downstream target of miR-10b and showed that there was an inverse correlation between the expression of ITCH and miR-10b on melanoma tissues. Its down-regulation alleviates inhibitory effects of miR-10b inhibitor on melanoma cell proliferation migration and invasion.
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