B4DN26 · B4DN26_HUMAN
- Proteint-plasminogen activator
- GenePLAT
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids473 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 102 | Important for binding to LRP1 | ||||
Sequence: Y | ||||||
Active site | 268 | Charge relay system | ||||
Sequence: H | ||||||
Active site | 317 | Charge relay system | ||||
Sequence: D | ||||||
Site | 375 | Important for single-chain activity | ||||
Sequence: K | ||||||
Site | 423 | Important for single-chain activity | ||||
Sequence: D | ||||||
Active site | 424 | Charge relay system | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | plasminogen activation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namet-plasminogen activator
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB4DN26
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 579 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MDAMKRGLCCVLLLCGAVFVSP | ||||||
Chain | PRO_5014567682 | 23-473 | t-plasminogen activator | |||
Sequence: SQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP | ||||||
Disulfide bond | 41↔71 | |||||
Sequence: CRDEKTQMIYQQHQSWLRPVLRSNRVEYCWC | ||||||
Disulfide bond | 69↔78 | |||||
Sequence: CWCNSGRAQC | ||||||
Disulfide bond | 86↔97 | |||||
Sequence: CSEPRCFNGGTC | ||||||
Disulfide bond | 91↔108 | |||||
Sequence: CFNGGTCQQALYFSDFVC | ||||||
Disulfide bond | 110↔119 | |||||
Sequence: CPEGFAGKCC | ||||||
Disulfide bond | 126↔207 | |||||
Sequence: CYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSC | ||||||
Disulfide bond | 147↔189 | |||||
Sequence: CLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWC | ||||||
Disulfide bond | 178↔202 | |||||
Sequence: CRNPDGDAKPWCHVLKNRRLTWEYC | ||||||
Disulfide bond | 210↔341 | Interchain (between A and B chains) | ||||
Sequence: CGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVC | ||||||
Disulfide bond | 253↔269 | |||||
Sequence: CGGILISSCWILSAAHC | ||||||
Disulfide bond | 261↔330 | |||||
Sequence: CWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRC | ||||||
Disulfide bond | 355↔430 | |||||
Sequence: CELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVC | ||||||
Disulfide bond | 387↔403 | |||||
Sequence: CTSQHLLNRTVTDNMLC | ||||||
Disulfide bond | 420↔448 | |||||
Sequence: CQGDSGGPLVCLNDGRMTLVGIISWGLGC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 39-81 | Fibronectin type-I | ||||
Sequence: VICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSV | ||||||
Region | 42-52 | Important for binding to annexin A2 | ||||
Sequence: RDEKTQMIYQQ | ||||||
Domain | 82-120 | EGF-like | ||||
Sequence: PVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE | ||||||
Domain | 125-207 | Kringle | ||||
Sequence: DCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSC | ||||||
Domain | 222-472 | Peptidase S1 | ||||
Sequence: IKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMR |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length473
- Mass (Da)52,992
- Last updated2008-09-23 v1
- ChecksumAC4FB758DDF91A1D
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P00750 | TPA_HUMAN | PLAT | 562 | ||
E7ESF4 | E7ESF4_HUMAN | PLAT | 499 | ||
H0YBH9 | H0YBH9_HUMAN | PLAT | 96 | ||
B4DNJ1 | B4DNJ1_HUMAN | PLAT | 436 | ||
A0A7I2YQ93 | A0A7I2YQ93_HUMAN | PLAT | 583 | ||
A0A7I2V268 | A0A7I2V268_HUMAN | PLAT | 182 | ||
A0A7I2V6D6 | A0A7I2V6D6_HUMAN | PLAT | 392 | ||
E5RGA1 | E5RGA1_HUMAN | PLAT | 178 | ||
E5RHG4 | E5RHG4_HUMAN | PLAT | 157 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC083973 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC103724 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AK297738 EMBL· GenBank· DDBJ | BAG60088.1 EMBL· GenBank· DDBJ | mRNA |