B4DN26 · B4DN26_HUMAN

  • Protein
    t-plasminogen activator
  • Gene
    PLAT
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
    EC:3.4.21.68 (UniProtKB | ENZYME | Rhea)

Features

Showing features for site, active site.

147350100150200250300350400450
TypeIDPosition(s)Description
Site102Important for binding to LRP1
Active site268Charge relay system
Active site317Charge relay system
Site375Important for single-chain activity
Site423Important for single-chain activity
Active site424Charge relay system

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionserine-type endopeptidase activity
Biological Processplasminogen activation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    t-plasminogen activator
  • EC number

Gene names

    • Name
      PLAT

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B4DN26

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 579 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_501456768223-473t-plasminogen activator
Disulfide bond41↔71
Disulfide bond69↔78
Disulfide bond86↔97
Disulfide bond91↔108
Disulfide bond110↔119
Disulfide bond126↔207
Disulfide bond147↔189
Disulfide bond178↔202
Disulfide bond210↔341Interchain (between A and B chains)
Disulfide bond253↔269
Disulfide bond261↔330
Disulfide bond355↔430
Disulfide bond387↔403
Disulfide bond420↔448

Keywords

Proteomic databases

Expression

Gene expression databases

    • ENSG00000104368Expressed in stromal cell of endometrium and 191 other cell types or tissues

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain39-81Fibronectin type-I
Region42-52Important for binding to annexin A2
Domain82-120EGF-like
Domain125-207Kringle
Domain222-472Peptidase S1

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    473
  • Mass (Da)
    52,992
  • Last updated
    2008-09-23 v1
  • Checksum
    AC4FB758DDF91A1D
MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P00750TPA_HUMANPLAT562
E7ESF4E7ESF4_HUMANPLAT499
H0YBH9H0YBH9_HUMANPLAT96
B4DNJ1B4DNJ1_HUMANPLAT436
A0A7I2YQ93A0A7I2YQ93_HUMANPLAT583
A0A7I2V268A0A7I2V268_HUMANPLAT182
A0A7I2V6D6A0A7I2V6D6_HUMANPLAT392
E5RGA1E5RGA1_HUMANPLAT178
E5RHG4E5RHG4_HUMANPLAT157

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC083973
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC103724
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AK297738
EMBL· GenBank· DDBJ
BAG60088.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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