B4DMZ5 · B4DMZ5_HUMAN

  • Protein
    Cholesteryl ester transfer protein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.

Catalytic activity

GO annotations

AspectTerm
Cellular Componenthigh-density lipoprotein particle
Molecular Functioncholesterol binding
Molecular Functioncholesterol transfer activity
Molecular Functionphosphatidylcholine binding
Molecular Functionphospholipid transporter activity
Molecular Functiontriglyceride binding
Biological Processcholesterol homeostasis
Biological Processcholesterol metabolic process
Biological Processhigh-density lipoprotein particle remodeling
Biological Processlow-density lipoprotein particle remodeling
Biological Processphosphatidylcholine metabolic process
Biological Processphospholipid homeostasis
Biological Processreverse cholesterol transport
Biological Processtriglyceride homeostasis
Biological Processtriglyceride metabolic process
Biological Processtriglyceride transport
Biological Processvery-low-density lipoprotein particle remodeling

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cholesteryl ester transfer protein

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B4DMZ5

Subcellular Location

Secreted
Note: Secreted in plasma.

Keywords

  • Cellular component

Disease & Variants

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_501521917518-433Cholesteryl ester transfer protein
Disulfide bond160↔201

Keywords

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain31-259Lipid-binding serum glycoprotein N-terminal
Domain222-416Lipid-binding serum glycoprotein C-terminal

Sequence similarities

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    433
  • Mass (Da)
    47,801
  • Last updated
    2008-09-23 v1
  • Checksum
    36C4476AE66F78E5
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESIQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK297699
EMBL· GenBank· DDBJ
BAG60057.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp