B4DMH2 · B4DMH2_HUMAN
- ProteinCellular tumor antigen p53
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids368 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for site, binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | mitochondrial matrix | |
Cellular Component | PML body | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | apoptotic process | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | protein tetramerization | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCellular tumor antigen p53
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB4DMH2
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Cross-link | 266 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
Interaction
Subunit
Binds DNA as a homotetramer.
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-30 | p53 transactivation | ||||
Sequence: SDPSVEPPLSQETFSDLWKLLPENN | ||||||
Domain | 35-58 | Cellular tumor antigen p53 transactivation | ||||
Sequence: LPSQAMDDLMLSPDDIEQWFTEDP | ||||||
Domain | 75-263 | p53 DNA-binding | ||||
Sequence: QKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPAQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEEN | ||||||
Compositional bias | 257-276 | Basic and acidic residues | ||||
Sequence: RRTEEENLRKKGEPHHELPP | ||||||
Region | 257-300 | Disordered | ||||
Sequence: RRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDG | ||||||
Compositional bias | 280-294 | Polar residues | ||||
Sequence: KRALPNNTSSSPQPK | ||||||
Domain | 294-332 | p53 tetramerisation | ||||
Sequence: KKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGK | ||||||
Region | 326-368 | Disordered | ||||
Sequence: KDAQAGKEPGGGRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD | ||||||
Compositional bias | 341-355 | Basic residues | ||||
Sequence: SSHLKSKKGQSTSRH |
Sequence similarities
Belongs to the p53 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length368
- Mass (Da)41,236
- Last updated2008-09-23 v1
- Checksum72CB5AA6E9DAD30A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 257-276 | Basic and acidic residues | ||||
Sequence: RRTEEENLRKKGEPHHELPP | ||||||
Compositional bias | 280-294 | Polar residues | ||||
Sequence: KRALPNNTSSSPQPK | ||||||
Compositional bias | 341-355 | Basic residues | ||||
Sequence: SSHLKSKKGQSTSRH |