The transporters PEPT2 PHT1 and PHT2 are responsible for the uptake of carnosine into glioblastoma cells and full function of all three transporters is required for maximum uptake.
Two novel genes SLC15A2 (rs1143671 and rs1143672) and SLCO1B3 (rs4149117 and rs7311358) are associated with the warfarin maintenance dose in a Chinese population.
PEPT2 is functionally expressed in H441 cells making the cell line a good in vitro model to study PEPT2 function and its regulation in human distal lung.
anserine is recognized by the proton-coupled peptide transporters PEPT1 and PEPT2 with medium affinity. Anserine is able to displace other substrates from the transport process.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator); Higher blood lead burden in children with the PEPT2*2 mutation may suggest that this common genetic variant is a biomarker of increased vulnerability to the neurotoxic effects of lowest level lead exposure.
PEPT2 polymorphism distributions differ significantly between Chinese Malay and Asian Indian populations. Cephalexin pharmacokinetics were not different between Chinese and Asian Indians; Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
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