The DI/VF sequence motif of BDAJB6 acts as a crucial switch that determines the state of the entire Hsp40-Hsp70 machine and eventually chaperone activity and cell death or survival.
this study shows that DNAJB1/HSP40 suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein function in conjunction with HSP70
Authors identified DNAJB1 as a negative regulator of PDCD5-mediated apoptosis and found that the apoptosis network of PDCD5 regulates cancer cell death.
Cellular localization studies showed that NP and Hsp40 co-localize primarily in the nucleus. During IAV infection in mammalian cells expression of NP coincided with the dissociation of P58(IPK) from Hsp40 and decrease PKR phosphorylation
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.