Hsp70- and Hsp90-Mediated Regulation of the Conformation of p53 DNA Binding Domain and p53 Cancer Variants.
- AnnotationThe analyzed cancer mutants are likewise destabilized by interaction with the Hsp70/Hdj1 system. In contrast Hsp90 protects the DBD of p53 wild-type and mutant proteins from unfolding. We propose that the Hsp70 and Hsp90 chaperone systems assume complementary functions to optimally balance conformational plasticity with conformational stability.
- CategoryFunction
- SourceGeneRif: 3337