METTL14 inhibits malignant progression of oral squamous cell carcinoma by targeting the autophagy-related gene RB1CC1 in an m6A-IGF2BP2-dependent manner.
RB1CC1 functions as a tumor-suppressing gene in renal cell carcinoma via suppression of PYK2 activity and disruption of TAZ-mediated PDL1 transcription activation.
we show that essential for anti-bacterial autophagy the cargo receptor NDP52 forms a trimeric complex with FIP200 and SINTBAD/NAP1 which are subunits of the autophagy-initiating ULK and the TBK1 kinase complex respectively. FIP200 and SINTBAD/NAP1 are each recruited independently to bacteria via NDP52 as revealed by selective point mutations in their respective binding sites
the recruitment of the FIP200 CTR slows the phase separation of ubiquitinated proteins by p62 in a reconstituted system. Our data provide the molecular basis for a crosstalk between cargo condensation and autophagosome formation.
These findings suggested that PHF8 played an oncogenic role in facilitating FIP200-dependent autophagic degradation of E-cadherin EMT and metastasis in hepatocellular carcinoma (HCC). PHF8 might be a promising target for prevention treatment and prognostic prediction of HCC.
Data suggest that in patients with diabetic kidney disease urinary excretion of mRNAs for MAP1LC3A WIPI2 and RB1CC1 is down-regulated as compared to healthy control subjects; these transcripts may serve as urinary autophagy biomarkers. (MAP1LC3A = microtubule associated protein 1 light chain 3; WIPI2 = WD repeat domain phosphoinositide-interacting protein 2; RB1CC1 = RB1 inducible coiled-coil 1)
This is the first report demonstrating that polymorphisms in the autophagy-related FIP200 gene may predict hypertension in patients with mCRC treated with FOLFIRI and bevacizumab.
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