The ARD1-mediated protein acetylation plays an important role in modulating several cellular events that are important for cancer development such as cell cycle progression cell death and migration.
Data suggest a model where reduced N(alpha)-acetyltransferase 10 N(alpha)-acetyltransferase 10 NatA catalytic subunit (NAA10) activity cause the phenotypes observed in the two patients.
higher expression level of Naa10 and lower expression level of Pirh2 in oral squamous cell carcinoma tissues than adjacent normal tissues; expression of Naa10p is negatively correlated with that of Pirh2
We reviewed recognised variants in PAS associated with Mendelian disorders and identified only 23 others indicating that NAA10 harbours more than 10% of all known PAS variants.
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