PPP2R1A mutations occur in a subset of gastrointestinal stromal tumors and are associated with a high malignant potential that leads to decreased disease-free survival and overall survival
This study indicates that the PPP2R1A mutation occurs at a lower frequency compared to other gynecological malignancies irrespective of the histological subtype
the frequent mutation of PPP2R1A in the serous type of uterine cancer a low frequency of mutation in endometrioid endometrial cancer and absence of mutation in uterine carcinosarcoma.
identified somatic missense mutations in 40.8% of high-grade serous endometrial tumours and 5% of endometrial endometrioid carcinomas; mutations identified in ovarian tumours at lower frequencies;no mutations found in high- or low-grade serous carcinoma
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