B3VA59 · AGLC_METVO

  • Protein
    Dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase
  • Gene
    aglC
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Involved in the assembly of an N-linked disaccharide that decorates the S-layer glycoprotein and flagellins (PubMed:18978056).
AglC catalyzes the transfer of 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid (Glc-2,3-diNAcA) from uridine 5'-diphospho 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid (UDP-Glc-2,3-diNAcA) to the AglK product Dol-P-GlcNAc to yield Dol-P-GlcNAc-Glc-2,3-diNAcA (PubMed:23624439).
AglC is specific for the monophosphate-linked Dol-P-GlcNAc (PubMed:23624439).

Catalytic activity

Pathway

Cell surface structure biogenesis; S-layer biogenesis.
Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionhexosyltransferase activity
Biological ProcessN-glycan processing
Biological Processprotein glycosylation
Biological ProcessS-layer organization

Keywords

Enzyme and pathway databases

Protein family/group databases

    • GT2Glycosyltransferase Family 2

Names & Taxonomy

Protein names

  • Recommended name
    Dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase
  • EC number
  • Alternative names
    • Glc-2,3-diNAcA glycosyltransferase
    • UDP-Glc-2,3-diNAcA glycosyltransferase

Gene names

    • Name
      aglC

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 33273 / DSM 1537 / NBRC 100457 / OCM 70 / PS
  • Taxonomic lineage
    Archaea > Euryarchaeota > Methanomada group > Methanococci > Methanococcales > Methanococcaceae > Methanococcus

Accessions

  • Primary accession
    B3VA59

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane252-272Helical
Transmembrane290-310Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Cells lacking this gene result in flagellins and S-layer proteins with significantly reduced apparent molecular masses, loss of flagellar assembly and absence of glycan attachment.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004356541-321Dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    321
  • Mass (Da)
    37,328
  • Last updated
    2008-09-02 v1
  • Checksum
    4225C4DC1DB03D5A
MNFISIIIPTFNEEKYITKCLENWFNQDYPKENYEILIFDGKSTDKTLDVIKELQKKHNFENIKIYTNEKRKQVYAFNEGIKNANGDFFIIFGAHAYPEQDFLKNNIETYQRIKKEEPKLAGVGGIINKISENMSAEIAKVIYSTPLSGGSSFWYAKEGFFSNTVVYGMYDTKMIKESEILFDTDFITGQDFEFNLHLIKEGFKLYTNPNIVSSYYTRSSVKKFIKQTISYGAAKGLMIRKGYFNILWLFPFGFLFMLLSIIITGLLIFIYIMAILIDTIRLLIKTREPLYIALPILLFLFHCLISYGFFKGLIKGNSTFK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU726231
EMBL· GenBank· DDBJ
ACE74695.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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