B3R2J3 · RRAAH_CUPTR
- ProteinPutative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids165 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
Catalytic activity
- 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate
Cofactor
Note: Divalent metal cation.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxaloacetate decarboxylase activity | |
Molecular Function | ribonuclease inhibitor activity | |
Biological Process | regulation of RNA metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
- EC number
- Short namesHMG aldolase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Cupriavidus
Accessions
- Primary accessionB3R2J3
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000125597 | 1-165 | Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase | |||
Sequence: MKPVTTDLCDAHEDRLAEGTLRVMAPVFRAFGKQPAFAGPAATLKVFEDNSLVRATLESPGRGRVLVIDGGGSLRCALVGGNLGLLAEKNGWVGIVVNGCIRDTAELDVCDIGIRALAAHPQKSQKRNVGESEVTVQMPGAVVRPGNWIYVDVDGILVADDKLER |
Interaction
Subunit
Homotrimer.
Structure
Sequence
- Sequence statusComplete
- Length165
- Mass (Da)17,532
- Last updated2008-09-02 v1
- Checksum5E44558C80B85792
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU633749 EMBL· GenBank· DDBJ | CAQ69711.1 EMBL· GenBank· DDBJ | Genomic DNA |