B3R2J3 · RRAAH_CUPTR

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Divalent metal cation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site80-83substrate
Binding site102substrate
Binding site103a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
Molecular Functionmetal ion binding
Molecular Functionoxaloacetate decarboxylase activity
Molecular Functionribonuclease inhibitor activity
Biological Processregulation of RNA metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Short names
    HMG aldolase
  • Alternative names
    • Oxaloacetate decarboxylase (OAA decarboxylase) (EC:4.1.1.112) . EC:4.1.1.112 (UniProtKB | ENZYME | Rhea)
    • Regulator of ribonuclease activity homolog
    • RraA-like protein

Gene names

    • Ordered locus names
      RALTA_A1769

Organism names

Accessions

  • Primary accession
    B3R2J3

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001255971-165Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

Interaction

Subunit

Homotrimer.

Structure

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    165
  • Mass (Da)
    17,532
  • Last updated
    2008-09-02 v1
  • Checksum
    5E44558C80B85792
MKPVTTDLCDAHEDRLAEGTLRVMAPVFRAFGKQPAFAGPAATLKVFEDNSLVRATLESPGRGRVLVIDGGGSLRCALVGGNLGLLAEKNGWVGIVVNGCIRDTAELDVCDIGIRALAAHPQKSQKRNVGESEVTVQMPGAVVRPGNWIYVDVDGILVADDKLER

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU633749
EMBL· GenBank· DDBJ
CAQ69711.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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