B3NVK4 · B3NVK4_DROER

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site269Nucleophile
Active site353
Active site355

GO annotations

AspectTerm
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (ammonia) activity
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functiondihydroorotase activity
Molecular Functionglutaminase activity
Molecular Functionmetal ion binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Submitted names
    • Uncharacterized protein
      (EC:2.1.3.2
      , EC:3.5.2.-
      )

Gene names

    • Name
      Dere\GG19065
    • ORF names
      Dere_GG19065

Organism names

  • Taxonomic identifier
  • Strain
    • TSC#14021-0224.01
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    B3NVK4

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain529-721ATP-grasp
Domain1066-1257ATP-grasp
Domain1322-1477MGS-like

Sequence similarities

In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,224
  • Mass (Da)
    246,257
  • Last updated
    2008-09-02 v1
  • Checksum
    A16DC48AE5DE4CB4
MAQANCYLALEDGTVLPGYSFGYVPSDQTSKVAVGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNYGVPAPDEDEHGLPLHFEWMKGVVQASALVVGEVADAAWHWRKWKTLPDWLQQHKVPGIRDIDTRALTKKLREQGSMLGKIVYERPPEDGLPKSSFEDPNVRNLAKECSVRERQVYGDPNGKGPRIAILDCGLKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGPGNPESCDEVVQQVRQVIEEGRKPVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDLQQLPDGWSELFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFLESIKQKDLTIPQLIEQRLRPTRIAKDPAPVKPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIATVQTSKGMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVELERAGVFSKYNVRILGTPIQSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAEALDAASRLGYPVMARAAFSLGGLGSGFANNEQELQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYDNCITVCNMENFDPLGIHTGESIVVAPSQTLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSVGEVMAIGRNFEEAFQKALRMVDGDVLGFDPDVVPLDKEKLADQLSEPTDRRPFVLAAALELGMSISELHRLTNIDCWFLDKLERIIALRSHLARVGSRFDAVLLLKAKRFGFSDKQIAKAIKSTELAVRHQRQEFGIRPHVKQIDTVAGEWPASTNYLYNTYNGSEHDVDFPGGHTIVVGSGVYRIGSSVEFDWCAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILSMGGQLPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCEEVGYPCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVAADGRILCMAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAKNNELKVIECNVRVSRSFPFVSKTLDHDFVATATRAIVGLDVEPLDVLHGVGKVGVKVPQFSFSRLAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSIGSFKHKMELLPSIRDLAKMGYKLYASMGTGDFYAEHGVDVESVQWTFDKTTPDDINGELRHLAEFLANKQFDLVINLPMSGGGARRVSSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMRMNGGKPPMKTHTDCMTSRRIVKLPGFIDMHVHLREPGATHKEDFASGTAAALAGGVTLVCAMPNTNPSIVDRETFTQFQELAKAGARCDYALYVGASDENWAQVNELASQACGLKMYLNNTFGTLKLSDMTSWQRHLTHWPKRAPVVCHAEKQSTAAVILLAHLLDRSVHICHVARKEEILLIRAAKEKGIKVTCEVCPHHLFLSTKDVERLGHGMSEVRPLLCSPEDQEALWENIDYIDVFATDHAPHTLAEKRSEHPPPGFPGVETILPLLLQAVHEGRLTLEDIKRKFHRNPRIIFNLPDQAHTYVEVDLDEEWTITGSEMKSKSGWTPFEGTKVKGRVHRVVLRGEVAFIDGQVLVQPGFGLNVRAKQGQLTSEASLDLLPSDNDANDTFARLLTADGAGAGAHGTSTKVHFVDGANYLRPTSPSPRVRLDSASNTTLREYLQRTSSPNPVAHSLVGKHILAVDMFNKEHLNDIFNLAQLLKLRVTKDRPVDELLRGKIMASVFYEVSTRTQCSFAAAMLRLGGRVISMDQITSSVKKGESLEDSIKVMASYADVMVLRHPTPGAVARAATFSRKPVINAGDGVGEHPTQALLDIFTIREEIGTVNGLTITMVGDLKNGRTVHSLARLLTLYNVTLKYVAPPSLQMPNEVVQFVHQRGIKQFFATSLYDVLPDTDVLYMTRIQRERFENVADYEKCCGHLLLTSELMTLAKKRSIVLHPLPRLEEISRDIDSDPRAAYFRQAEYGMYIRMALLAMVVGGRNTAL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH954180
EMBL· GenBank· DDBJ
EDV46396.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp