B3LQ66 · LPLA_YEAS1

Function

function

Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.

Miscellaneous

In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

Pathway

Protein modification; protein lipoylation via exogenous pathway; protein N6-(lipoyl)lysine from lipoate: step 1/2.
Protein modification; protein lipoylation via exogenous pathway; protein N6-(lipoyl)lysine from lipoate: step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site188ATP (UniProtKB | ChEBI)
Binding site193-196ATP (UniProtKB | ChEBI)
Binding site249(R)-lipoate (UniProtKB | ChEBI)
Binding site249ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular FunctionATP binding
Molecular Functionlipoate-protein ligase activity
Molecular Functionlipoyltransferase activity
Biological Processprotein lipoylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative lipoate-protein ligase A
  • EC number
  • Alternative names
    • Altered inheritance rate of mitochondria protein 22

Gene names

    • Name
      AIM22
    • ORF names
      SCRG_03625

Organism names

Accessions

  • Primary accession
    B3LQ66

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003776681-409Putative lipoate-protein ligase A

Interaction

Subunit

Monomer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain146-330BPL/LPL catalytic

Sequence similarities

Belongs to the LplA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    409
  • Mass (Da)
    47,032
  • Last updated
    2008-09-02 v1
  • Checksum
    FEDFE85D4D17E0DC
MSMMLSNWALSPRYVGQRNLIHCTTLFHTLTRWAKDADDKYHDINSMYENMFTPSNDNVSILQDEGKSDYDTTKTSSMQEDISAFNKDLYNFYNIGYAKQIMSASQLENIVKAKGRFVIQSLSTSPYYNLALENYVFKNTPRAKRGPDNCRLLFYINDRCAVIGKNQNLWQEVDLAKLKSKNFELLRRFSGGGTVLHDLGNVNYSYLTSREKFETKFFNKMIIKWLNSLNPELRLDLNERGDIIQDGFKISGSAYKIAGGKAYHHATMLLNADLEQFSGLLEPSLPNNMEWESSGVHSVKSKIKNVGIITPNQFIAVVSERFQKTFKVDGEIPIYYCDEFKSINDEIKDAMNTLQSEQWKYFSGPKFSVKIKDKGLTIKVEKGMIYDCDRNDLIGLEFKGFLENIDSYT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH408050
EMBL· GenBank· DDBJ
EDV12719.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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