B3KVN7 · B3KVN7_HUMAN
- Proteinadenylate cyclase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids924 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 146 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 146 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 146-151 | ATP (UniProtKB | ChEBI) | |||
Binding site | 147 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 188-190 | ATP (UniProtKB | ChEBI) | |||
Binding site | 190 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 190 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 234 | ATP (UniProtKB | ChEBI) | |||
Binding site | 772 | ATP (UniProtKB | ChEBI) | |||
Binding site | 852-854 | ATP (UniProtKB | ChEBI) | |||
Binding site | 859-863 | ATP (UniProtKB | ChEBI) | |||
Binding site | 899 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameadenylate cyclase
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB3KVN7
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 39-58 | Helical | |||
Transmembrane | 433-454 | Helical | |||
Transmembrane | 460-485 | Helical | |||
Transmembrane | 513-534 | Helical | |||
Transmembrane | 572-590 | Helical | |||
Transmembrane | 597-615 | Helical | |||
Transmembrane | 635-653 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 141-268 | Guanylate cyclase | |||
Domain | 720-865 | Guanylate cyclase | |||
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length924
- Mass (Da)104,261
- Last updated2008-09-02 v1
- MD5 ChecksumB5630F4A9B2DCA3CFF024931CA2332D7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK123013 EMBL· GenBank· DDBJ | BAG53849.1 EMBL· GenBank· DDBJ | mRNA |