B3KVN7 · B3KVN7_HUMAN

  • Protein
    adenylate cyclase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

1924100200300400500600700800900
TypeIDPosition(s)Description
Binding site146Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site146Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site146-151ATP (UniProtKB | ChEBI)
Binding site147Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site188-190ATP (UniProtKB | ChEBI)
Binding site190Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site190Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site234ATP (UniProtKB | ChEBI)
Binding site772ATP (UniProtKB | ChEBI)
Binding site852-854ATP (UniProtKB | ChEBI)
Binding site859-863ATP (UniProtKB | ChEBI)
Binding site899ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionadenylate cyclase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological ProcesscAMP biosynthetic process
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    adenylate cyclase
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B3KVN7

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane39-58Helical
Transmembrane433-454Helical
Transmembrane460-485Helical
Transmembrane513-534Helical
Transmembrane572-590Helical
Transmembrane597-615Helical
Transmembrane635-653Helical

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain141-268Guanylate cyclase
Domain720-865Guanylate cyclase

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    924
  • Mass (Da)
    104,261
  • Last updated
    2008-09-02 v1
  • MD5 Checksum
    B5630F4A9B2DCA3CFF024931CA2332D7
MLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKILIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKGGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNVAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK123013
EMBL· GenBank· DDBJ
BAG53849.1
EMBL· GenBank· DDBJ
mRNA

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