B3KTR3 · B3KTR3_HUMAN
- ProteinChloride intracellular channel protein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids233 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- bromide(in) = bromide(out)
- chloride(in) = chloride(out)
- choline(out) = choline(in)
- fluoride(in) = fluoride(out)
- iodide(out) = iodide(in)
- nitrate(in) = nitrate(out)
- thiocyanate(in) = thiocyanate(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | anchoring junction | |
Cellular Component | centrosome | |
Cellular Component | chloride channel complex | |
Cellular Component | cytoplasmic vesicle membrane | |
Cellular Component | mitochondrion | |
Cellular Component | plasma membrane | |
Molecular Function | chloride channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameChloride intracellular channel protein
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB3KTR3
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle membrane ; Single-pass membrane protein
Membrane ; Single-pass membrane protein
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 61-224 | GST C-terminal | ||||
Sequence: NSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRLEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAY |
Domain
Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
Sequence similarities
Belongs to the chloride channel CLIC family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length233
- Mass (Da)26,694
- Last updated2008-09-02 v1
- Checksum9120E9D6E41B8B09