B3KQM3 · B3KQM3_HUMAN
- ProteinReceptor-interacting serine/threonine-protein kinase 2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids540 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | protein tyrosine kinase activity | |
Biological Process | adaptive immune response | |
Biological Process | innate immune response | |
Biological Process | positive regulation of apoptotic process | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameReceptor-interacting serine/threonine-protein kinase 2
- EC number
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB3KQM3
Subcellular Location
PTM/Processing
Interaction
Subunit
Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 18-294 | Protein kinase | ||||
Sequence: LADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITREVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVL | ||||||
Compositional bias | 338-368 | Polar residues | ||||
Sequence: NHGPQEESCGSSQLHENSGSPETSRSLPAPQ | ||||||
Region | 338-369 | Disordered | ||||
Sequence: NHGPQEESCGSSQLHENSGSPETSRSLPAPQD | ||||||
Domain | 432-524 | CARD | ||||
Sequence: QPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEIL |
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length540
- Mass (Da)61,066
- Last updated2008-09-02 v1
- Checksum83C3DF93FD021C3B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 338-368 | Polar residues | ||||
Sequence: NHGPQEESCGSSQLHENSGSPETSRSLPAPQ |