cryo-electron microscopy structure of the monoubiquitinated human ID complex (involving the proteins FANCI and FANCD2) bound to DNA and reveal that it forms a closed ring that encircles the DNA
show that FANCI localizes to the nucleolus and is functionally and physically tied to the transcription of pre-ribosomal RNA (pre-rRNA) and to large ribosomal subunit (LSU) pre-rRNA processing independent of FANCD2
FANCB dimer coordinates FANCD2:FANCI monoubiquitination by two FANCL RING-ligases. Deubiquitination of FANCD2:FANCI by USP1:UAF1 occurs only when DNA is removed.
These findings indicate that FANCI functions upstream of FA core complex recruitment independently of FANCD2 and alter the current view of the FA-BRCA pathway.
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