B3KNM3 · B3KNM3_HUMAN
- Proteinadenylate cyclase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1090 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 324 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 324 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 324-329 | ATP (UniProtKB | ChEBI) | |||
Binding site | 325 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 366-368 | ATP (UniProtKB | ChEBI) | |||
Binding site | 368 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 368 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 412 | ATP (UniProtKB | ChEBI) | |||
Binding site | 921 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1008-1010 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1015-1019 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1055 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameadenylate cyclase
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB3KNM3
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 78-100 | Helical | |||
Transmembrane | 106-126 | Helical | |||
Transmembrane | 138-157 | Helical | |||
Transmembrane | 169-185 | Helical | |||
Transmembrane | 190-210 | Helical | |||
Transmembrane | 230-247 | Helical | |||
Transmembrane | 633-653 | Helical | |||
Transmembrane | 665-687 | Helical | |||
Transmembrane | 708-741 | Helical | |||
Transmembrane | 786-803 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 319-446 | Guanylate cyclase | |||
Compositional bias | 504-544 | Polar residues | |||
Region | 504-566 | Disordered | |||
Domain | 869-1021 | Guanylate cyclase | |||
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,090
- Mass (Da)123,060
- Last updated2008-09-02 v1
- MD5 Checksum645F53E10DF91614A3F42E0B305C8CA2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 504-544 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK027857 EMBL· GenBank· DDBJ | BAG51385.1 EMBL· GenBank· DDBJ | mRNA |