B3GSH5 · ASMT_RAT
- ProteinAcetylserotonin O-methyltransferase
- GeneAsmt
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids432 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
Miscellaneous
Pineal melatonin synthesis is severely compromised in most inbred strains. In many inbred strains, genetic defects in ASMT have been identified. Melatonin production may have an impact on gonadal development, testis development being significantly promoted in melatonin-deficient C57BL/6J x Mus musculus molossinus animals.
Catalytic activity
- N-acetylserotonin + S-adenosyl-L-methionine = H+ + melatonin + S-adenosyl-L-homocysteineThis reaction proceeds in the forward direction.
Pathway
Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 146 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 163 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 209 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 235-237 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: GDF | ||||||
Binding site | 252 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 255 | Proton donor/acceptor | ||||
Sequence: H | ||||||
Binding site | 256 | substrate | ||||
Sequence: D | ||||||
Binding site | 302 | substrate | ||||
Sequence: N | ||||||
Binding site | 306 | substrate | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | acetylserotonin O-methyltransferase activity | |
Molecular Function | identical protein binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | S-adenosylmethionine-dependent methyltransferase activity | |
Biological Process | lipid metabolic process | |
Biological Process | male gonad development | |
Biological Process | melatonin biosynthetic process | |
Biological Process | methylation | |
Biological Process | negative regulation of male gonad development |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAcetylserotonin O-methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionB3GSH5
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000414796 | 1-432 | Acetylserotonin O-methyltransferase | |||
Sequence: MAPGREGELDRDFRVLMSLAHGFMVSQVLFAALDLGIFDLAAQGPVAAEAVAQTGGWSPRGTQLLMDACTRLGLLRGAGDGSYTNSALSSTFLVSGSPQSQRCMLLYLAGTTYGCWAHLAAGVREGRNQYSRAVGISAEDPFSAIYRSEPERLLFMRGLQETWSLCGGRVLTAFDLSRFRVICDLGGGSGALAQEAARLYPGSSVCVFDLPDVIAAARTHFLSPGARPSVRFVAGDFFRSRLPRADLFILARVLHDWADGACVELLGRLHRACRPGGALLLVEAVLAKGGAGPLRSLLLSLNMMLQAEGWERQASDYRNLATRAGFPRLQLRRPGGPYHAMLARRGPRPGIITGVGSNTTGTGSFVTGIRRDVPGARSDAAGTGSGTGNTGSGIMLQGETLESEVSAPQAGSDVGGAGNEPRSGTLKQGDWK |
Proteomic databases
Expression
Tissue specificity
Expressed predominantly in the pineal gland (at protein level). Very low expression, if any, in the retina.
Induction
Exhibits very slight night/day variation, if any.
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 373-432 | Disordered | ||||
Sequence: VPGARSDAAGTGSGTGNTGSGIMLQGETLESEVSAPQAGSDVGGAGNEPRSGTLKQGDWK | ||||||
Compositional bias | 382-407 | Polar residues | ||||
Sequence: GTGSGTGNTGSGIMLQGETLESEVSA |
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length432
- Mass (Da)45,588
- Last updated2008-07-22 v1
- Checksum0F782CD0AB6293F5
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3G1CV13 | A0A3G1CV13_RAT | Asmt | 383 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 382-407 | Polar residues | ||||
Sequence: GTGSGTGNTGSGIMLQGETLESEVSA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L78306 EMBL· GenBank· DDBJ | AAB61243.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
EU741665 EMBL· GenBank· DDBJ | ACD87748.1 EMBL· GenBank· DDBJ | mRNA | ||
CH474012 EMBL· GenBank· DDBJ | EDL89812.1 EMBL· GenBank· DDBJ | Genomic DNA |