B3GS92 · B3GS92_RAT

Function

function

Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; molybdopterin biosynthesis.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentdendrite
Cellular Componentpostsynaptic specialization membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionmolybdopterin adenylyltransferase activity
Molecular Functionmolybdopterin molybdotransferase activity
Biological Processestablishment of synaptic specificity at neuromuscular junction
Biological Processgamma-aminobutyric acid receptor clustering
Biological Processglycine receptor clustering
Biological ProcessMo-molybdopterin cofactor biosynthetic process
Biological Processpostsynaptic neurotransmitter receptor diffusion trapping

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Gephyrin

Including 2 domains:

  • Recommended name
    Molybdopterin molybdenumtransferase
  • EC number
  • Short names
    MPT Mo-transferase
  • Alternative names
    • Domain E
  • Recommended name
    Molybdopterin adenylyltransferase
  • EC number
  • Short names
    MPT adenylyltransferase
  • Alternative names
    • Domain G

Gene names

    • Name
      Gphn

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    B3GS92

Organism-specific databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain12-159MoaB/Mog
Region175-226Disordered
Compositional bias200-219Basic and acidic residues
Region254-284Disordered
Domain496-639MoaB/Mog

Sequence similarities

Belongs to the MoeA family.
In the C-terminal section; belongs to the MoeA family.
In the N-terminal section; belongs to the MoaB/Mog family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    730
  • Mass (Da)
    79,132
  • Last updated
    2008-07-22 v1
  • Checksum
    3DCFA8D9E737CE12
MSFPLSPAFTLFHILVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPNEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias200-219Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU735541
EMBL· GenBank· DDBJ
ACE06970.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp