B3GS92 · B3GS92_RAT
- ProteinGephyrin
- GeneGphn
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids730 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Catalytic activity
- ATP + H+ + molybdopterin = adenylyl-molybdopterin + diphosphate
- adenylyl-molybdopterin + molybdate = AMP + H+ + Mo-molybdopterin
Cofactor
Pathway
Cofactor biosynthesis; molybdopterin biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | dendrite | |
Cellular Component | postsynaptic specialization membrane | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | molybdopterin adenylyltransferase activity | |
Molecular Function | molybdopterin molybdotransferase activity | |
Biological Process | establishment of synaptic specificity at neuromuscular junction | |
Biological Process | gamma-aminobutyric acid receptor clustering | |
Biological Process | glycine receptor clustering | |
Biological Process | Mo-molybdopterin cofactor biosynthetic process | |
Biological Process | postsynaptic neurotransmitter receptor diffusion trapping |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGephyrin
Including 2 domains:
- Recommended nameMolybdopterin molybdenumtransferase
- EC number
- Short namesMPT Mo-transferase
- Alternative names
- Recommended nameMolybdopterin adenylyltransferase
- EC number
- Short namesMPT adenylyltransferase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionB3GS92
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-159 | MoaB/Mog | ||||
Sequence: FHILVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPNEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHA | ||||||
Region | 175-226 | Disordered | ||||
Sequence: DELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSS | ||||||
Compositional bias | 200-219 | Basic and acidic residues | ||||
Sequence: EDKGVQCEEEEEEKKDSGVA | ||||||
Region | 254-284 | Disordered | ||||
Sequence: TASLSTTPSESPRAQATSRLSTASCPTPKVQ | ||||||
Domain | 496-639 | MoaB/Mog | ||||
Sequence: AVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRK |
Sequence similarities
Belongs to the MoeA family.
In the C-terminal section; belongs to the MoeA family.
In the N-terminal section; belongs to the MoaB/Mog family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length730
- Mass (Da)79,132
- Last updated2008-07-22 v1
- Checksum3DCFA8D9E737CE12
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 200-219 | Basic and acidic residues | ||||
Sequence: EDKGVQCEEEEEEKKDSGVA |