B3GNI6 · SEP11_RAT

Function

function

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity.

Features

Showing features for binding site.

143150100150200250300350400
TypeIDPosition(s)Description
Binding site48-55GTP (UniProtKB | ChEBI)
Binding site103GTP (UniProtKB | ChEBI)
Binding site184-192GTP (UniProtKB | ChEBI)
Binding site238GTP (UniProtKB | ChEBI)
Binding site253GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentcell division site
Cellular Componentdendritic spine
Cellular ComponentGABA-ergic synapse
Cellular Componentglutamatergic synapse
Cellular Componentmicrotubule cytoskeleton
Cellular Componentpostsynapse
Cellular Componentpostsynaptic specialization of symmetric synapse
Cellular Componentseptin complex
Cellular Componentseptin ring
Cellular Componentstress fiber
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmolecular adaptor activity
Biological Processcytoskeleton-dependent cytokinesis
Biological Processprotein localization
Biological Processregulation of synapse organization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Septin-11

Gene names

    • Name
      Septin11
    • Synonyms
      Sept11

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    B3GNI6
  • Secondary accessions
    • B3DMA8
    • B3GNI4

Proteomes

Organism-specific databases

Subcellular Location

Note: Partly colocalizes with stress fibers. Association with microtubules not observed in embryonic fibroblasts. In cultured hippocampal neurons, localizes to 54% of GABAergic and 25% of glutamatergic synapses. Frequently present at the base of dendritic protrusions and at the bifurcation points of the dendritic branches. Expressed at low levels in the axons of mature cultured hippocampal neurons. In embryonic fibroblasts, associated with actin stress fibers.

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine
ChainPRO_00003854762-431Septin-11
Modified residue9Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in cerebellum, olfactory bulb, hippocampus, cerebral cortex, thalamus, and corpus striatum. In the hippocampus, strong expression around the pyramidal cells of the stratum pyramidale and in the stratum lucidum of the CA2-CA3 regions. In the olfactory bulb, particularly strong expression in the external plexiform layer. In the cerebellum, concentrates in the molecular layer, particularly in Purkinje cells, where it is found at the base of dendritic spines/protrusions, at the dendritic branching points and in some GABAergic synapses.

Developmental stage

Expressed in the embryo and in early postnatal weeks. On and before P14, distributes in a homogeneous way, throughout the brain. By P21, high expression observed in the molecular layer of the cerebellum and in the olfactory bulb. The maximum expression and the adult pattern of distribution in the brain occurs by P30. By P30, P45 and P90, highest expression occurs in the molecular layer of the cerebellum and in the olfactory bulb, and relatively high expression in the hippocampus, cerebral cortex, thalamus and corpus striatum.

Gene expression databases

Interaction

Subunit

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules (By similarity).
Forms homooligomers (By similarity).
GTPase activity is required for filament formation (By similarity).
Interacts with SEPTIN7 (PubMed:15485874).
Interacts with SEPTIN9 and SEPTIN12 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, coiled coil, compositional bias.

TypeIDPosition(s)Description
Domain38-304Septin-type G
Region48-55G1 motif
Region100-103G3 motif
Region183-186G4 motif
Coiled coil320-408
Compositional bias400-415Polar residues
Region400-431Disordered
Compositional bias416-431Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

B3GNI6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    III
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    431
  • Mass (Da)
    49,695
  • Last updated
    2008-07-22 v1
  • Checksum
    CC838B791729B511
MAVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVSNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNPWLCTE

B3GNI6-2

  • Name
    2
  • Synonyms
    I, II
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

B3GNI6-3

  • Name
    3
  • Synonyms
    IV
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0G2JUL7A0A0G2JUL7_RATSeptin11429
A0A8I6AAG9A0A8I6AAG9_RATSeptin11426
A0A8L2QUR1A0A8L2QUR1_RATSeptin11429
A0A8I5ZNQ9A0A8I5ZNQ9_RATSeptin11426

Features

Showing features for compositional bias, alternative sequence.

TypeIDPosition(s)Description
Compositional bias400-415Polar residues
Compositional bias416-431Basic and acidic residues
Alternative sequenceVSP_038168425in isoform 2
Alternative sequenceVSP_038169426-431in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU711414
EMBL· GenBank· DDBJ
ACE00321.1
EMBL· GenBank· DDBJ
mRNA
EU711415
EMBL· GenBank· DDBJ
ACE00322.1
EMBL· GenBank· DDBJ
mRNA
EU711416
EMBL· GenBank· DDBJ
ACE00323.1
EMBL· GenBank· DDBJ
mRNA
EU711417
EMBL· GenBank· DDBJ
ACE00324.1
EMBL· GenBank· DDBJ
mRNA
CH474060
EMBL· GenBank· DDBJ
EDL88655.1
EMBL· GenBank· DDBJ
Genomic DNA
BC167769
EMBL· GenBank· DDBJ
AAI67769.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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