B3GNI6 · SEP11_RAT
- ProteinSeptin-11
- GeneSeptin11
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids431 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | cell division site | |
Cellular Component | dendritic spine | |
Cellular Component | GABA-ergic synapse | |
Cellular Component | glutamatergic synapse | |
Cellular Component | microtubule cytoskeleton | |
Cellular Component | postsynapse | |
Cellular Component | postsynaptic specialization of symmetric synapse | |
Cellular Component | septin complex | |
Cellular Component | septin ring | |
Cellular Component | stress fiber | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | molecular adaptor activity | |
Biological Process | cytoskeleton-dependent cytokinesis | |
Biological Process | protein localization | |
Biological Process | regulation of synapse organization |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSeptin-11
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionB3GNI6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Partly colocalizes with stress fibers. Association with microtubules not observed in embryonic fibroblasts. In cultured hippocampal neurons, localizes to 54% of GABAergic and 25% of glutamatergic synapses. Frequently present at the base of dendritic protrusions and at the bifurcation points of the dendritic branches. Expressed at low levels in the axons of mature cultured hippocampal neurons. In embryonic fibroblasts, associated with actin stress fibers.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylalanine | ||||
Sequence: A | ||||||
Chain | PRO_0000385476 | 2-431 | Septin-11 | |||
Sequence: AVAVGRPSNEELRNLSLSGHVGFDSLPDQLVNKSTSQGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVSNFQKKKAAAQLLQSQAQQSGAQQTKKDKDKKNPWLCTE | ||||||
Modified residue | 9 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in cerebellum, olfactory bulb, hippocampus, cerebral cortex, thalamus, and corpus striatum. In the hippocampus, strong expression around the pyramidal cells of the stratum pyramidale and in the stratum lucidum of the CA2-CA3 regions. In the olfactory bulb, particularly strong expression in the external plexiform layer. In the cerebellum, concentrates in the molecular layer, particularly in Purkinje cells, where it is found at the base of dendritic spines/protrusions, at the dendritic branching points and in some GABAergic synapses.
Developmental stage
Expressed in the embryo and in early postnatal weeks. On and before P14, distributes in a homogeneous way, throughout the brain. By P21, high expression observed in the molecular layer of the cerebellum and in the olfactory bulb. The maximum expression and the adult pattern of distribution in the brain occurs by P30. By P30, P45 and P90, highest expression occurs in the molecular layer of the cerebellum and in the olfactory bulb, and relatively high expression in the hippocampus, cerebral cortex, thalamus and corpus striatum.
Gene expression databases
Interaction
Subunit
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules (By similarity).
Forms homooligomers (By similarity).
GTPase activity is required for filament formation (By similarity).
Interacts with SEPTIN7 (PubMed:15485874).
Interacts with SEPTIN9 and SEPTIN12 (By similarity).
Forms homooligomers (By similarity).
GTPase activity is required for filament formation (By similarity).
Interacts with SEPTIN7 (PubMed:15485874).
Interacts with SEPTIN9 and SEPTIN12 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 38-304 | Septin-type G | ||||
Sequence: QGFCFNILCVGETGIGKSTLMDTLFNTKFESDPATHNEPGVRLKARSYELQESNVRLKLTIVDTVGFGDQINKDDSYKPIVEYIDAQFEAYLQEELKIKRSLFNYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTIAKNELHKFKSKIMSELVSNGVQIYQFPTDEETVAEINATMSVHLPFAVVGSTEEVKIGNKMAKARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHTRHYELYRRCKLEE | ||||||
Region | 48-55 | G1 motif | ||||
Sequence: GETGIGKS | ||||||
Region | 100-103 | G3 motif | ||||
Sequence: DTVG | ||||||
Region | 183-186 | G4 motif | ||||
Sequence: AKAD | ||||||
Coiled coil | 320-408 | |||||
Sequence: QETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEEKKKVEDKKKELEEEVSNFQKKKAAAQLLQSQ | ||||||
Compositional bias | 400-415 | Polar residues | ||||
Sequence: AAAQLLQSQAQQSGAQ | ||||||
Region | 400-431 | Disordered | ||||
Sequence: AAAQLLQSQAQQSGAQQTKKDKDKKNPWLCTE | ||||||
Compositional bias | 416-431 | Basic and acidic residues | ||||
Sequence: QTKKDKDKKNPWLCTE |
Sequence similarities
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
B3GNI6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsIII
- Length431
- Mass (Da)49,695
- Last updated2008-07-22 v1
- ChecksumCC838B791729B511
B3GNI6-2
- Name2
- SynonymsI, II
- Differences from canonical
- 425-425: N → NS
B3GNI6-3
- Name3
- SynonymsIV
- Differences from canonical
- 426-431: Missing
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0G2JUL7 | A0A0G2JUL7_RAT | Septin11 | 429 | ||
A0A8I6AAG9 | A0A8I6AAG9_RAT | Septin11 | 426 | ||
A0A8L2QUR1 | A0A8L2QUR1_RAT | Septin11 | 429 | ||
A0A8I5ZNQ9 | A0A8I5ZNQ9_RAT | Septin11 | 426 |
Features
Showing features for compositional bias, alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU711414 EMBL· GenBank· DDBJ | ACE00321.1 EMBL· GenBank· DDBJ | mRNA | ||
EU711415 EMBL· GenBank· DDBJ | ACE00322.1 EMBL· GenBank· DDBJ | mRNA | ||
EU711416 EMBL· GenBank· DDBJ | ACE00323.1 EMBL· GenBank· DDBJ | mRNA | ||
EU711417 EMBL· GenBank· DDBJ | ACE00324.1 EMBL· GenBank· DDBJ | mRNA | ||
CH474060 EMBL· GenBank· DDBJ | EDL88655.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC167769 EMBL· GenBank· DDBJ | AAI67769.1 EMBL· GenBank· DDBJ | mRNA |