B3ER47 · MRAY_AMOA5

Function

function

Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionphospho-N-acetylmuramoyl-pentapeptide-transferase activity
Molecular FunctionUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
Biological Processcell division
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
  • EC number
  • Alternative names
    • UDP-MurNAc-pentapeptide phosphotransferase

Gene names

    • Name
      mraY
    • Ordered locus names
      Aasi_0256

Organism names

Accessions

  • Primary accession
    B3ER47

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-50Helical
Transmembrane73-93Helical
Transmembrane100-120Helical
Transmembrane132-152Helical
Transmembrane209-229Helical
Transmembrane242-262Helical
Transmembrane274-294Helical
Transmembrane301-321Helical
Transmembrane326-346Helical
Transmembrane381-401Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000905881-404Phospho-N-acetylmuramoyl-pentapeptide-transferase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    404
  • Mass (Da)
    45,209
  • Last updated
    2008-07-22 v1
  • Checksum
    EDE0B20118F0E825
MLYYFFKYIDRFSHIPGIGVFKYISFRAASAAILSLCISIFLGKRLIIFFKTAQIKEGIRELDLAGQSEKAHIPTMGGIIIIAATVVPTLLFAKLKNVYIMLLLISIIWMGLIGFIDDYIKVFKRDKKGLAGKFKIVGQVALGVIVGITLIFRDDVVIREFGSNITVIENGQVTINDYKDVKTVKTTIPFLKNNELDYSKLIPWLDSKYMWIVYVLFMIFIIAAVSNGANLTDGLDGLTAGTSAIIGTTLAILAYVSGNVIFSRYLNIMYIPNLAELAIFCTAFVGACVGFLWYNTYPAQIFMGDTGSLAIGSVIAVLAIVIRKELMIPLLCGIFFIETLSVIIQVGYFKYTKYRYGIGKRMFKMAPLHHHFQKLGFHESKIVTRFWIVGIVLAILSLVTLKLR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001102
EMBL· GenBank· DDBJ
ACE05699.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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