B3E1J2 · B3E1J2_TRIL1
- ProteinAdenosylhomocysteinase
- GeneahcY
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids464 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Catalytic activity
- S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 55 | substrate | |||
Binding site | 130 | substrate | |||
Binding site | 190 | substrate | |||
Binding site | 191-193 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 220 | substrate | |||
Binding site | 224 | substrate | |||
Binding site | 225 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 254-259 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 256-261 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 277 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 312 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 333-335 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 378 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 385 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | adenosylhomocysteinase activity | |
Biological Process | L-homocysteine biosynthetic process | |
Biological Process | one-carbon metabolic process | |
Biological Process | S-adenosylmethionine cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosylhomocysteinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfuromonadia > Geobacterales > Geobacteraceae > Trichlorobacter
Accessions
- Primary accessionB3E1J2
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 225-384 | S-adenosyl-L-homocysteine hydrolase NAD binding | |||
Sequence similarities
Belongs to the adenosylhomocysteinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length464
- Mass (Da)50,826
- Last updated2008-07-22 v1
- Checksum06B959E9AC10E1B3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001089 EMBL· GenBank· DDBJ | ACD94084.1 EMBL· GenBank· DDBJ | Genomic DNA |