Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

B3E1F5 · B3E1F5_METI4

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site32-34shikimate (UniProtKB | ChEBI)
Binding site79shikimate (UniProtKB | ChEBI)
Active site83Proton acceptor
Binding site104shikimate (UniProtKB | ChEBI)
Binding site119shikimate (UniProtKB | ChEBI)
Binding site168-173NADP+ (UniProtKB | ChEBI)
Binding site238NADP+ (UniProtKB | ChEBI)
Binding site240shikimate (UniProtKB | ChEBI)
Binding site261NADP+ (UniProtKB | ChEBI)
Binding site268shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • Ordered locus names
      Minf_2478

Organism names

Accessions

  • Primary accession
    B3E1F5

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-106Shikimate dehydrogenase substrate binding N-terminal
Domain128-210Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Domain261-290SDH C-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    293
  • Mass (Da)
    32,576
  • Last updated
    2008-07-22 v1
  • MD5 Checksum
    7419D6B522CD08D9A6160C29E13105F7
MSEKTYFRLKDFKEFYPTGPCYAVLGKPIAHSLSPVFQKAAFRQLALDADYIRIEVAEEELEQAVNLLVEKGFLGWNCTSPLKKKMASLCNTLDNSAALLGSVNTVVRKEQRLLGYNTDGRGWAIDVKKNFAVDFQNLSIAILGTGGAGEAIAKQSAIEGSKKLILLNRTYEKALLLARSIEKNFEVEVQVLPLTESSLKQLMLKSDLFVQSLPLLPFLSLNFQWEKILDPKVILYDVLYFPIPTPMESVAKKIGSKVVNGLGMLVEQGALSFSIWTGLDAPIETMRRSVHLS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000975
EMBL· GenBank· DDBJ
ACD84532.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help