B3E181 · B3E181_METI4

Function

function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site17-22ATP (UniProtKB | ChEBI)
Binding site38AMP (UniProtKB | ChEBI)
Binding site43AMP (UniProtKB | ChEBI)
Binding site63-65AMP (UniProtKB | ChEBI)
Binding site105AMP (UniProtKB | ChEBI)
Binding site136ATP (UniProtKB | ChEBI)
Binding site142AMP (UniProtKB | ChEBI)
Binding site153AMP (UniProtKB | ChEBI)
Binding site180ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Biological ProcessAMP salvage
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase
  • EC number
  • Short names
    AK
  • Alternative names
    • ATP-AMP transphosphorylase
    • ATP:AMP phosphotransferase
    • Adenylate monophosphate kinase

Gene names

    • Name
      adk
    • Ordered locus names
      Minf_0822

Organism names

Accessions

  • Primary accession
    B3E181

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    194
  • Mass (Da)
    22,214
  • Last updated
    2008-07-22 v1
  • Checksum
    482CAC725A026458
MKAKVKYNSLLLIGAPGSGKGTQGKILGTIPGFFHFSSGELFRSVNAQSPVGKTFLEYSSKGLLVPDEITIQLFCSYMEKVITEGRFRPKLDYLVLDGLPRNVSQWHILSEQVEVLYVYHLHCPDRSILEARLKGRASSDHRVDDTEEVIQKRFEVYEKETKPLLELFPSERLKEIDCTRMPYQVLRQILEPLP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000975
EMBL· GenBank· DDBJ
ACD82877.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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