B3DY25 · B3DY25_METI4
- Protein4-hydroxy-tetrahydrodipicolinate reductase
- GenedapB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids263 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Catalytic activity
- (S)-2,3,4,5-tetrahydrodipicolinate + NAD+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 22-27 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 48 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 49 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 90-92 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 114-117 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 147 | Proton donor/acceptor | |||
Binding site | 148 | (S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI) | |||
Active site | 151 | Proton donor | |||
Binding site | 157-158 | (S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 4-hydroxy-tetrahydrodipicolinate reductase | |
Molecular Function | NAD binding | |
Molecular Function | NADP binding | |
Molecular Function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-tetrahydrodipicolinate reductase
- EC number
- Short namesHTPA reductase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Verrucomicrobiota > Methylacidiphilae > Methylacidiphilales > Methylacidiphilaceae > Methylacidiphilum (ex Ratnadevi et al. 2023)
Accessions
- Primary accessionB3DY25
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 16-117 | Dihydrodipicolinate reductase N-terminal | |||
Domain | 120-252 | Dihydrodipicolinate reductase C-terminal | |||
Sequence similarities
Belongs to the DapB family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length263
- Mass (Da)28,548
- Last updated2008-07-22 v1
- MD5 ChecksumBC9A4B9F668B6ADCDB88C94164EC13E2
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000975 EMBL· GenBank· DDBJ | ACD83977.1 EMBL· GenBank· DDBJ | Genomic DNA |