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B3DY25 · B3DY25_METI4

Function

function

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Caution

Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site22-27NAD+ (UniProtKB | ChEBI)
Binding site48NAD+ (UniProtKB | ChEBI)
Binding site49NADP+ (UniProtKB | ChEBI)
Binding site90-92NAD+ (UniProtKB | ChEBI)
Binding site114-117NAD+ (UniProtKB | ChEBI)
Active site147Proton donor/acceptor
Binding site148(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)
Active site151Proton donor
Binding site157-158(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate reductase
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate reductase
  • EC number
  • Short names
    HTPA reductase

Gene names

    • Name
      dapB
    • Ordered locus names
      Minf_1923

Organism names

Accessions

  • Primary accession
    B3DY25

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-117Dihydrodipicolinate reductase N-terminal
Domain120-252Dihydrodipicolinate reductase C-terminal

Sequence similarities

Belongs to the DapB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    263
  • Mass (Da)
    28,548
  • Last updated
    2008-07-22 v1
  • MD5 Checksum
    BC9A4B9F668B6ADCDB88C94164EC13E2
MVHETKNPAEGTRAMIRILLTGAGGKMGQTVVQAAALDPEVKIVGLVDKEDKLEDLLVKEVDCIIDFSVHHFSPELVRKAMSRSVPLVMGTTGHSPEELAEIKQAAQKIPIVLSPNFSLGINAMEFLVRIASLVLGKSYDKDVIDIHHNTKLDSPSGTAKRLLEVLVEAEEKGDEGLGQKAEKNPRNRLPQVHSIRAGTVVGVHTVMYCGPGEVIEITHRAENRFPFALGSLKAAKWIIGKAPALYSMKDVLGLDRITSVLAL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000975
EMBL· GenBank· DDBJ
ACD83977.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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