B3DQB4 · LEXA_BIFLD

Function

function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

Catalytic activity

  • Hydrolysis of Ala-|-Gly bond in repressor LexA.
    EC:3.4.21.88 (UniProtKB | ENZYME | Rhea)

Features

Showing features for dna binding, site, active site.

124120406080100120140160180200220240
Type
IDPosition(s)Description
DNA binding41-61H-T-H motif
Site130-131Cleavage; by autolysis
Active site165For autocatalytic cleavage activity
Active site202For autocatalytic cleavage activity

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular Functionserine-type endopeptidase activity
Biological ProcessDNA repair
Biological ProcessDNA replication
Biological Processnegative regulation of DNA-templated transcription
Biological Processproteolysis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    LexA repressor
  • EC number

Gene names

    • Name
      lexA
    • Ordered locus names
      BLD_0167

Organism names

Accessions

  • Primary accession
    B3DQB4

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000895471-241LexA repressor

Keywords

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase S24 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    26,049
  • Last updated
    2008-07-22 v1
  • Checksum
    E8A4C6300737A9D3
MSTIPFSPKQKPDESTLTDRQRKVLDAIRTHIDEQGFAPSFREIGNAAGLKSPSSVKHQLQVLEDKGFIRMNANKGRAIEVVAGSAPNAEKPSQASEEATSTSNVAEIYQFPAEAIAESHDVPLVGRIAAGVPITAEQHVDDVMRLPERLTGSGTLFMLEVHGDSMVDAAICDGDYVVVREQNSAVNGDIVAALLDDEATVKTFRKENGHVWLMPHNPAYSPIDGTHATIMGKVVTVLRKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000605
EMBL· GenBank· DDBJ
ACD97613.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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