B3DQB4 · LEXA_BIFLD
- ProteinLexA repressor
- GenelexA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids241 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Catalytic activity
Features
Showing features for dna binding, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
DNA binding | 41-61 | H-T-H motif | |||
Site | 130-131 | Cleavage; by autolysis | |||
Active site | 165 | For autocatalytic cleavage activity | |||
Active site | 202 | For autocatalytic cleavage activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | DNA repair | |
Biological Process | DNA replication | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | SOS response |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLexA repressor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Bifidobacteriales > Bifidobacteriaceae > Bifidobacterium
Accessions
- Primary accessionB3DQB4
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000089547 | 1-241 | LexA repressor | ||
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length241
- Mass (Da)26,049
- Last updated2008-07-22 v1
- ChecksumE8A4C6300737A9D3
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000605 EMBL· GenBank· DDBJ | ACD97613.1 EMBL· GenBank· DDBJ | Genomic DNA |