B3DNN5 · CDC16_ARATH
- ProteinAnaphase-promoting complex subunit 6
- GeneAPC6
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids543 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication.
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Biological Process | cell division | |
Biological Process | phloem or xylem histogenesis | |
Biological Process | protein ubiquitination | |
Biological Process | regulation of DNA endoreduplication |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAnaphase-promoting complex subunit 6
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionB3DNN5
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Gametophytic lethal phenotype.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 20 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000396844 | 1-543 | Anaphase-promoting complex subunit 6 | |||
Sequence: MREEEIEKIRGVVRDCVSKHLYSSAIFFADKVAALTNDPSDIYMQAQALFLGRHYRRAFHLLNASKIVLRDLRFRYLAAKCLEELKEWDQCLLMLGDAKVDDDGIVYDAKDGNVIDFDKDGEDREINISSAICFLRGKAYGALQNRSQARQWYKAAIKADPLCYEALECLIESHMLTSEEESSLLSSLQFSPEDGWLSSFYSCLIKKYDKESTVELKFKKLENETSGSVSGSSMITLANNTDLLACKAEYYHQCCEYQKCFELTAALLEKDPFHLKCTLVHLAAAMELGNSNELYLMACNLVKDYPSKALSWFAVGCYYYCIKKYAEARRYFSKATGIDGSFSPARIGYGNSFAAQEEGDQAMSAYRTAARLFPGCHLPTLYIGMEYMRTHSYKLADQFFMQAKAICPSDPLVYNELGVVAYHMKEYGKAVRWFEKTLAHIPSALTESWEPTVVNLAHAYRKLRKDREAISYYERALTLSTKSLSTYSGLAYTYHLQGNFSAAISYYHKALWLKPDDQFCTEMLNVALMDECQNGVDSKVELC |
Proteomic databases
Expression
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 7-36 | TPR 1 | ||||
Sequence: EKIRGVVRDCVSKHLYSSAIFFADKVAALT | ||||||
Repeat | 39-64 | TPR 2 | ||||
Sequence: PSDIYMQAQALFLGRHYRRAFHLLNA | ||||||
Repeat | 72-95 | TPR 3 | ||||
Sequence: LRFRYLAAKCLEELKEWDQCLLML | ||||||
Repeat | 128-159 | TPR 4 | ||||
Sequence: ISSAICFLRGKAYGALQNRSQARQWYKAAIKA | ||||||
Repeat | 164-187 | TPR 5 | ||||
Sequence: YEALECLIESHMLTSEEESSLLSS | ||||||
Repeat | 194-232 | TPR 6 | ||||
Sequence: DGWLSSFYSCLIKKYDKESTVELKFKKLENETSGSVSGS | ||||||
Repeat | 242-270 | TPR 7 | ||||
Sequence: DLLACKAEYYHQCCEYQKCFELTAALLEK | ||||||
Repeat | 277-304 | TPR 8 | ||||
Sequence: CTLVHLAAAMELGNSNELYLMACNLVKD | ||||||
Repeat | 309-338 | TPR 9 | ||||
Sequence: ALSWFAVGCYYYCIKKYAEARRYFSKATGI | ||||||
Repeat | 343-371 | TPR 10 | ||||
Sequence: SPARIGYGNSFAAQEEGDQAMSAYRTAAR | ||||||
Repeat | 378-406 | TPR 11 | ||||
Sequence: LPTLYIGMEYMRTHSYKLADQFFMQAKAI | ||||||
Repeat | 411-443 | TPR 12 | ||||
Sequence: PLVYNELGVVAYHMKEYGKAVRWFEKTLAHIPS | ||||||
Repeat | 447-479 | TPR 13 | ||||
Sequence: ESWEPTVVNLAHAYRKLRKDREAISYYERALTL | ||||||
Repeat | 484-513 | TPR 14 | ||||
Sequence: LSTYSGLAYTYHLQGNFSAAISYYHKALWL |
Sequence similarities
Belongs to the APC6/CDC16 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length543
- Mass (Da)61,762
- Last updated2008-07-22 v1
- Checksum87A97D87BC29E36D
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF529177 EMBL· GenBank· DDBJ | AAM95623.1 EMBL· GenBank· DDBJ | mRNA | ||
AC005679 EMBL· GenBank· DDBJ | AAC83033.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002684 EMBL· GenBank· DDBJ | AEE36148.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT033023 EMBL· GenBank· DDBJ | ACE62891.1 EMBL· GenBank· DDBJ | mRNA | ||
AY085381 EMBL· GenBank· DDBJ | AAM62610.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK118058 EMBL· GenBank· DDBJ | BAC42689.1 EMBL· GenBank· DDBJ | mRNA |