B3DIG4 · FZD5_DANRE
- ProteinFrizzled-5
- Genefzd5
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids592 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Receptor for Wnt proteins (By similarity).
Following binding, activates the canonical Wnt/beta-catenin signaling pathway (By similarity).
Also activates wnt non-canonical signaling (PubMed:15996547).
In neurons, activation of the Wnt pathway promotes formation of synapses (By similarity).
May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in early eye development, possibly through wnt non-canonical signaling (PubMed:15996547).
As a receptor for wnt11, promotes eye formation, at least partially, by antagonizing the Wnt/beta-catenin pathway (PubMed:15996547).
In addition, promotes coherence of eye field cells, potentially contributing to the coordinated morphogenetic behaviors of cells in the nascent eye field (PubMed:15996547).
Following binding, activates the canonical Wnt/beta-catenin signaling pathway (By similarity).
Also activates wnt non-canonical signaling (PubMed:15996547).
In neurons, activation of the Wnt pathway promotes formation of synapses (By similarity).
May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in early eye development, possibly through wnt non-canonical signaling (PubMed:15996547).
As a receptor for wnt11, promotes eye formation, at least partially, by antagonizing the Wnt/beta-catenin pathway (PubMed:15996547).
In addition, promotes coherence of eye field cells, potentially contributing to the coordinated morphogenetic behaviors of cells in the nascent eye field (PubMed:15996547).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | dendrite | |
Cellular Component | Golgi membrane | |
Cellular Component | perikaryon | |
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | lipid binding | |
Molecular Function | Wnt receptor activity | |
Molecular Function | Wnt-protein binding | |
Biological Process | camera-type eye development | |
Biological Process | canonical Wnt signaling pathway | |
Biological Process | cell differentiation | |
Biological Process | eye development | |
Biological Process | liver development | |
Biological Process | negative regulation of canonical Wnt signaling pathway | |
Biological Process | non-canonical Wnt signaling pathway | |
Biological Process | swim bladder development | |
Biological Process | Wnt signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFrizzled-5
- Short namesFz-5
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionB3DIG4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Note: Localized at the plasma membrane and also found at the Golgi apparatus.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 39-248 | Extracellular | ||||
Sequence: ASKDIVCEPITVPMCKGIGYNHTYMPNQFNHDNQDEVGLEVHQFWPLVRIHCSPDLLFFLCSMYTPICLQDYKKPLPPCRSVCERAKRGCSPLMIQYGFEWPERMSCEQLPMLGDTDRLCMDRNSSETTTLSPPFPKPTPKGTPRHRATAKSAPPQKCDRECHCRGPLVPIKKEAHPLHNRVNTGSLPNCALPCHQPYFSQDERTFTTFW | ||||||
Transmembrane | 249-269 | Helical | ||||
Sequence: IGLWSVLCFVSTFTTVATFLI | ||||||
Topological domain | 270-280 | Cytoplasmic | ||||
Sequence: DMERFKYPERP | ||||||
Transmembrane | 281-301 | Helical | ||||
Sequence: IIFLAACYLFVSLGYIVRLLA | ||||||
Topological domain | 302-327 | Extracellular | ||||
Sequence: GHERVACEGTGDQQHILYDTTGPALC | ||||||
Transmembrane | 328-348 | Helical | ||||
Sequence: TLVFLLIYFFGMASSIWWVVL | ||||||
Topological domain | 349-370 | Cytoplasmic | ||||
Sequence: SFTWFLAAGMKWGNEAIAGYSQ | ||||||
Transmembrane | 371-391 | Helical | ||||
Sequence: YFHLAAWLVPSVKSIAVLALS | ||||||
Topological domain | 392-414 | Extracellular | ||||
Sequence: SVDGDPVAGICYVGNQSLEGLRG | ||||||
Transmembrane | 415-435 | Helical | ||||
Sequence: FVLAPLVVYLFTGSLFLLAGF | ||||||
Topological domain | 436-461 | Cytoplasmic | ||||
Sequence: VSLFRIRSVIKQGGTKTDKLEKLMIR | ||||||
Transmembrane | 462-482 | Helical | ||||
Sequence: IGLFTVLYTVPATIVVACLVY | ||||||
Topological domain | 483-512 | Extracellular | ||||
Sequence: EQHYRPSWERALACSCPSERQRLGMGPDYA | ||||||
Transmembrane | 513-533 | Helical | ||||
Sequence: VFMLKYFMCLVVGITSGVWIW | ||||||
Topological domain | 534-592 | Cytoplasmic | ||||
Sequence: SGKTLESWRRFIARYVPCRTRKPPVSASSMYSEASTALTARAGTAPTGTYHKSAPSSHV |
Keywords
- Cellular component
Phenotypes & Variants
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-38 | |||||
Sequence: MRKPADEHHFTMETSGMHLVGFWLHVLLLFQLSGLGDS | ||||||
Chain | PRO_5035035770 | 39-592 | Frizzled-5 | |||
Sequence: ASKDIVCEPITVPMCKGIGYNHTYMPNQFNHDNQDEVGLEVHQFWPLVRIHCSPDLLFFLCSMYTPICLQDYKKPLPPCRSVCERAKRGCSPLMIQYGFEWPERMSCEQLPMLGDTDRLCMDRNSSETTTLSPPFPKPTPKGTPRHRATAKSAPPQKCDRECHCRGPLVPIKKEAHPLHNRVNTGSLPNCALPCHQPYFSQDERTFTTFWIGLWSVLCFVSTFTTVATFLIDMERFKYPERPIIFLAACYLFVSLGYIVRLLAGHERVACEGTGDQQHILYDTTGPALCTLVFLLIYFFGMASSIWWVVLSFTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLEGLRGFVLAPLVVYLFTGSLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGLFTVLYTVPATIVVACLVYEQHYRPSWERALACSCPSERQRLGMGPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRRFIARYVPCRTRKPPVSASSMYSEASTALTARAGTAPTGTYHKSAPSSHV | ||||||
Disulfide bond | 45↔106 | |||||
Sequence: CEPITVPMCKGIGYNHTYMPNQFNHDNQDEVGLEVHQFWPLVRIHCSPDLLFFLCSMYTPIC | ||||||
Disulfide bond | 53↔99 | |||||
Sequence: CKGIGYNHTYMPNQFNHDNQDEVGLEVHQFWPLVRIHCSPDLLFFLC | ||||||
Disulfide bond | 90↔128 | |||||
Sequence: CSPDLLFFLCSMYTPICLQDYKKPLPPCRSVCERAKRGC | ||||||
Disulfide bond | 117↔158 | |||||
Sequence: CRSVCERAKRGCSPLMIQYGFEWPERMSCEQLPMLGDTDRLC | ||||||
Disulfide bond | 121↔145 | |||||
Sequence: CERAKRGCSPLMIQYGFEWPERMSC |
Keywords
- PTM
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 40-161 | FZ | ||||
Sequence: SKDIVCEPITVPMCKGIGYNHTYMPNQFNHDNQDEVGLEVHQFWPLVRIHCSPDLLFFLCSMYTPICLQDYKKPLPPCRSVCERAKRGCSPLMIQYGFEWPERMSCEQLPMLGDTDRLCMDR | ||||||
Region | 162-192 | Disordered | ||||
Sequence: NSSETTTLSPPFPKPTPKGTPRHRATAKSAP |
Sequence similarities
Belongs to the G-protein coupled receptor Fz/Smo family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length592
- Mass (Da)66,490
- Last updated2008-07-22 v1
- ChecksumFCFDE4C5CBDEC90E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FQ377896 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC163118 EMBL· GenBank· DDBJ | AAI63118.1 EMBL· GenBank· DDBJ | mRNA | ||
BC163120 EMBL· GenBank· DDBJ | AAI63120.1 EMBL· GenBank· DDBJ | mRNA |