B3DE35 · B3DE35_HUMAN

  • Protein
    Cytochrome c oxidase subunit 3
  • Gene
    COX3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular Functioncytochrome-c oxidase activity
Biological Processaerobic electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 3

Gene names

    • Name
      COX3

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Mdmd27
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B3DE35

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-35Helical
Transmembrane41-58Helical
Transmembrane79-102Helical
Transmembrane159-177Helical
Transmembrane197-220Helical
Transmembrane240-260Helical

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-261Heme-copper oxidase subunit III family profile

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    261
  • Mass (Da)
    29,937
  • Last updated
    2008-07-22 v1
  • Checksum
    B3FBBE6CDF1B62FB
MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMIQALLITVLLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT726132
EMBL· GenBank· DDBJ
ANA95522.1
EMBL· GenBank· DDBJ
Genomic DNA
KT726133
EMBL· GenBank· DDBJ
ANA95535.1
EMBL· GenBank· DDBJ
Genomic DNA
KT726134
EMBL· GenBank· DDBJ
ANA95548.1
EMBL· GenBank· DDBJ
Genomic DNA
KT726135
EMBL· GenBank· DDBJ
ANA95561.1
EMBL· GenBank· DDBJ
Genomic DNA
KT726142
EMBL· GenBank· DDBJ
ANA95652.1
EMBL· GenBank· DDBJ
Genomic DNA
AP009445
EMBL· GenBank· DDBJ
BAG39051.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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