B2YAP0 · B2YAP0_HUMAN

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

138050100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processrespiratory electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      CYTB

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • EvOh1
    • DR6
    • KR103
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B2YAP0

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-56Helical
Transmembrane77-98Helical
Transmembrane113-133Helical
Transmembrane140-158Helical
Transmembrane178-200Helical
Transmembrane229-246Helical
Transmembrane288-308Helical
Transmembrane320-339Helical
Transmembrane345-372Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-380Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    42,686
  • Last updated
    2008-07-01 v1
  • Checksum
    7DA658E69BFEAF8A
MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWVIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALAALHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU482359
EMBL· GenBank· DDBJ
ACA22604.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383622
EMBL· GenBank· DDBJ
ACM75224.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ951563
EMBL· GenBank· DDBJ
ACQ75542.1
EMBL· GenBank· DDBJ
Genomic DNA
HM357815
EMBL· GenBank· DDBJ
ADI79483.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824821
EMBL· GenBank· DDBJ
AEG62233.1
EMBL· GenBank· DDBJ
Genomic DNA
JN645821
EMBL· GenBank· DDBJ
AEP83533.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ044958
EMBL· GenBank· DDBJ
AEV49033.1
EMBL· GenBank· DDBJ
Genomic DNA
KC252520
EMBL· GenBank· DDBJ
AGX92149.1
EMBL· GenBank· DDBJ
Genomic DNA
KF451533
EMBL· GenBank· DDBJ
AGZ73574.1
EMBL· GenBank· DDBJ
Genomic DNA
KF148205
EMBL· GenBank· DDBJ
AGZ97524.1
EMBL· GenBank· DDBJ
Genomic DNA
KF849959
EMBL· GenBank· DDBJ
AHE79367.1
EMBL· GenBank· DDBJ
Genomic DNA
KU131376
EMBL· GenBank· DDBJ
AMB50789.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456457
EMBL· GenBank· DDBJ
APD52983.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272576
EMBL· GenBank· DDBJ
AVL84920.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449154
EMBL· GenBank· DDBJ
AYW06723.1
EMBL· GenBank· DDBJ
Genomic DNA
MH499878
EMBL· GenBank· DDBJ
QBX96213.1
EMBL· GenBank· DDBJ
Genomic DNA
MT419103
EMBL· GenBank· DDBJ
QMP92872.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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