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B2WMQ2 · AMPP3_PYRTR

Function

function

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.

Catalytic activity

  • Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
    EC:3.4.11.9 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site.

146350100150200250300350400450
TypeIDPosition(s)Description
Binding site259Mn2+ 2 (UniProtKB | ChEBI)
Binding site270Mn2+ 1 (UniProtKB | ChEBI)
Binding site270Mn2+ 2 (UniProtKB | ChEBI)
Binding site393Mn2+ 1 (UniProtKB | ChEBI)
Binding site433Mn2+ 1 (UniProtKB | ChEBI)
Binding site433Mn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable Xaa-Pro aminopeptidase pepP
  • EC number
  • Alternative names
    • Aminoacylproline aminopeptidase
    • Prolidase

Gene names

    • Name
      pepP
    • ORF names
      PTRG_11262

Organism names

Accessions

  • Primary accession
    B2WMQ2

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004118861-463Probable Xaa-Pro aminopeptidase pepP

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase M24B family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    463
  • Mass (Da)
    52,110
  • Last updated
    2008-07-01 v1
  • MD5 Checksum
    A970B5B681E0933880589CF91E1535AA
MAIAENYEDVLKGKYPAKAHAKKVAEWIIAKGGDKNGTIYLEAQKQKLNEDNDGEAPFRQRRYFFYLSGCELPDSYLTYEIATEKLTLFIPPVEPDEVIWSGLPMSPEEAKEKYDIDQCLTTKDVNAHLTSTSESAQSTIYAIPEQVSDHITFISYKEKEFKQLKPAIEYCRVIKSDYEIALIRKANIISTAAHEAVMKAASTAKNECELEAVFLKACVERNAKNQAYHSIVAAGEHAATLHYVHNAAPISDQNLLLLDAGCEVDCYASDITRTFPLKGKFTTESLAIYKIVLDMQHQCINALKEGVVWDSVHELAHKVAIKGLLELGILKGDAEEIFTKRISVAFFPHGLGHYLGMDTHDTGGNPNYADKDVMFRYLRTRGSLPERSVITVEPGVYFCRFIIEPYLKDEEKKKYIDESVLEKYWSVGGVRIEDNVLVTKNGFENLTPTPKEIDDITKLILST

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS231630
EMBL· GenBank· DDBJ
EDU44312.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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