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B2WLB5 · B2WLB5_PYRTR

Function

function

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site21Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity

GO annotations

AspectTerm
Cellular Componentchromosome, subtelomeric region
Cellular Componentchromosome, telomeric repeat region
Cellular ComponentKu70:Ku80 complex
Cellular Componentpericentric heterochromatin
Cellular Componentsite of double-strand break
Molecular FunctionATP binding
Molecular Functiondamaged DNA binding
Molecular FunctionDNA helicase activity
Molecular Functiondouble-stranded DNA binding
Molecular Functionhydrolase activity
Molecular Functiontelomeric DNA binding
Biological ProcessDNA recombination
Biological Processdouble-strand break repair via nonhomologous end joining
Biological Processstalled replication fork localization to nuclear periphery
Biological Processtelomere maintenance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase II subunit 1
  • EC number
  • Alternative names
    • ATP-dependent DNA helicase II subunit Ku70

Gene names

    • ORF names
      PTRG_10775

Organism names

Accessions

  • Primary accession
    B2WLB5

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-21Disordered
Region34-54Disordered
Region553-616Disordered
Compositional bias560-597Basic and acidic residues
Domain616-650SAP

Sequence similarities

Belongs to the ku70 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    655
  • Mass (Da)
    73,315
  • Last updated
    2008-07-01 v1
  • MD5 Checksum
    ED1FC73D87D05556A4193ED14C779522
MADPQDNRAGEEEEEEEDNYKTIKDAVLFAIDVSPSMLQKPPKSDDKKAERDSPTSAALKCAYQLMQQRIISNPNDMMGILLFGTEKTDVGDGDNAFEHCYLLADLDVPSAQDVKRLRDMVDNEEEAEEILKPAKGGASISNVLFCANQIFTTKAPNFSSRRLFLVTDNDYPVKIKADKDTAVTRARDLYDLGCTIDLFPISQPDHSFDRSRFYDDLVYPTSPSDPDAPVAISSTSKVAKSGEGISLLKQLISSINSKATPRRALFSLPLELGPDFRISVKGYILIKRQEHIKSCYVWVGGEKPQIATSSTTQISDDISRNIEKTELRKAYKFGGDAITFTPEEITQIRQCFGEPIIRIIGFKPLSSVPIWANTNKSTFIYPSEADYIGSTRVFSALQQKLIKSKKMGLVWFIPRRNAAPTLAALIPGVEKINEDGEQTMPPGLWLVPLPFADDIRQFPTPPEQPLKTTDALTDKMRLIIEQLQLPKGIYDPSRYPNPDLQWFYRILQALALEEELPDHPDDKTIPRYKQIDKRCGEYIEEYGKEFQEAYAQQHSEALAHRGKPVAKKRPAGGADADGKPAAKKVKKDPKVKAEDGDDEDGMTDEQMAELNNSGQISKQTVAVLKQWLVSRNQSTAGKKADLLERVQDYLDRKGL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias560-597Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS231629
EMBL· GenBank· DDBJ
EDU43825.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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