B2VX33 · B2VX33_PYRTR
- ProteinAcyl-coenzyme A diphosphatase SCS3
- GeneSCS3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1047 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
Catalytic activity
- (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
- (9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
- hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
- an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 208 | ||||
Active site | 289 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | alpha-galactosidase activity | |
Molecular Function | coenzyme A diphosphatase activity | |
Biological Process | carbohydrate catabolic process | |
Biological Process | lipid droplet formation | |
Biological Process | phospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAcyl-coenzyme A diphosphatase SCS3
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Pleosporineae > Pleosporaceae > Pyrenophora
Accessions
- Primary accessionB2VX33
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 43-64 | Helical | |||
Transmembrane | 104-122 | Helical | |||
Transmembrane | 134-152 | Helical | |||
Transmembrane | 205-227 | Helical | |||
Transmembrane | 269-289 | Helical | |||
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-36 | Disordered | |||
Compositional bias | 12-36 | Polar residues | |||
Domain | 398-580 | Glycosyl hydrolase family 36 N-terminal | |||
Domain | 954-1031 | Glycosyl hydrolase family 36 C-terminal | |||
Sequence similarities
Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,047
- Mass (Da)115,827
- Last updated2008-07-01 v1
- MD5 Checksum96999AB7E8B303BFE19C57C293D3D8F4
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 12-36 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS231615 EMBL· GenBank· DDBJ | EDU39708.1 EMBL· GenBank· DDBJ | Genomic DNA |