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B2VX33 · B2VX33_PYRTR

Function

function

Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site208
Active site289

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionalpha-galactosidase activity
Molecular Functioncoenzyme A diphosphatase activity
Biological Processcarbohydrate catabolic process
Biological Processlipid droplet formation
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acyl-coenzyme A diphosphatase SCS3
  • EC number
  • Alternative names
    • FIT family protein SCS3

Gene names

    • Name
      SCS3
    • Synonyms
      FIT2B
    • ORF names
      PTRG_00270

Organism names

Accessions

  • Primary accession
    B2VX33

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane43-64Helical
Transmembrane104-122Helical
Transmembrane134-152Helical
Transmembrane205-227Helical
Transmembrane269-289Helical

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-36Disordered
Compositional bias12-36Polar residues
Domain398-580Glycosyl hydrolase family 36 N-terminal
Domain954-1031Glycosyl hydrolase family 36 C-terminal

Sequence similarities

Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,047
  • Mass (Da)
    115,827
  • Last updated
    2008-07-01 v1
  • MD5 Checksum
    96999AB7E8B303BFE19C57C293D3D8F4
MATRRKLEASDSDNTQFSTSTSSDTMRPPTSSARRSPFLPTRLEAQLIAIYPITLLLGSIFSTLSPSTRSAPYSASLQSHPTEFAPSYFAQKKNVFNVYFVKVGWFWTTLAFTFFVTLHPGFGQGASARRIRAVLRYGLVTTWWCFLTQWFFGPPLIDRGFRFTGGQCELLRKSDAREDMSNTREYITAATCKAVGGTWKGGHDISGHVFLLILGSSLLWLEFLPALTHVEGLRDGRLITLPDGKVASVAVEKELVKEEGEATARGVKFALGVAGLMWWMLLMTAAYFHTWFEKFTGLLVAFAGLWTVYFLPRGASNDIRITPALLDAKASTSHGPDDKVDELTIKAAGTNFTLTADGMSYLFHVDTKTGDLISDHFGGPTTDFTPPAKINPSGWVDKLGNTRREFPDIGRGDFRLPAIHIEHADGDTVTAFRYQSHEIVDGKPGLPKLPATYGKVGDVTTVIVHMYDNVSDVSAALSYSIFPRYNAIARSFSISNNGSSDIVIERASSFSTDFPNLELEMIEPYGDWSHEFQTVKRKIDYGETSFRSTAGYASHLHNPFFTLVSPTTTESTGEAWGLQFGVDCIRVAPGATFQSPEAVGVYSSNGVGGMSRSFHDLYRNHLSRSKFTSQTRPILLNSWEGLGFNINETSLVKLAGEAEEIGIELFVMDDGWFGVEYPRNNDSMGLGDWTPNPAKFPSGLRPYVEQVNKFNILNSTTPLQFGIWVEPEMVNPNSTLYKEHPDWVLHAGKHERTLTRNQLVLNVGLTEVQDFIIDSVSRVLDSANIQYVKWDNNRGMHELARPSDDYTYILGLYRVIDTLTTKYPDVLFEGCASGGGRFDPGLLHYWSQHWTSDNTDASNRLTIQMGTSLVYPPSAMGCHVSAVPNQLTKRNISIEYRGHVAMMCGSFGLELNPSELSAEETALIPSIMAEAKAVNPIVISGHFYRLAHPDVSNWPGVQFVSADGAQAVVFAFQQSYMVKPAAPPLKLQGLDPKARYSNDLDNATYSGATYMNGGLNIPWPQGDYQSKLIWLNKVTANGSQAREAPIC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias12-36Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS231615
EMBL· GenBank· DDBJ
EDU39708.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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