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B2VUU7 · AMPP1_PYRTR

Function

function

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.

Catalytic activity

  • Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
    EC:3.4.11.9 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site.

159450100150200250300350400450500550
TypeIDPosition(s)Description
Binding site391Mn2+ 2 (UniProtKB | ChEBI)
Binding site402Mn2+ 1 (UniProtKB | ChEBI)
Binding site402Mn2+ 2 (UniProtKB | ChEBI)
Binding site500Mn2+ 1 (UniProtKB | ChEBI)
Binding site514Mn2+ 1 (UniProtKB | ChEBI)
Binding site514Mn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable Xaa-Pro aminopeptidase P
  • EC number
  • Short names
    AMPP; Aminopeptidase P
  • Alternative names
    • Aminoacylproline aminopeptidase
    • Prolidase

Gene names

    • Name
      ampp
    • ORF names
      PTRG_01084

Organism names

Accessions

  • Primary accession
    B2VUU7

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004118071-594Probable Xaa-Pro aminopeptidase P

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase M24B family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    594
  • Mass (Da)
    66,842
  • Last updated
    2008-07-01 v1
  • MD5 Checksum
    B12238B4F6CFA3334920C495A7526236
MAKVDTSHRLAELRKLMKERNVDIYTYISGFTGSAGYAVITHDKAALSTDGRYFNQAEKQLDSNWELLKQGIQDVPTIQEWTADQAEGGKVVGVDPSVVTAGDARKLAEKIKKKGGEYKAIDENLVDLVWSSERPARPSEKVIVQPERYACKGFEDKIDDLRKELEKKKSLGFVVSMLDEVAWLFNLRGSDIPYNPVFFSYAVVTPTAATLYVDENKLPEDVKEHLGNKITIRPYEAIFGDVTALSKELFEASDKNETQKKFLTSNRASWALNKALGGDDKVEETRSPVGDSKAVKNEVELEGMRQCHIRDGAALSEYFAWLEDQLINKKATLDEVDGADKLEEIRKKHDMFMGLSFDTISSTGANAAVIHYKPEKGECATIDPKAIYLCDSGAQYRDGTTDTTRTLHFTEPTEMERKAYTLVLKGNMALERVKFPKGTTGFALDALARQFLWAEGLDYRHGTGHGVGSFLNVHEGPIGIGTRVQYSEVSLAVGNVVSDEPGYYEDGKFGIRIENMVMVKEVETKHKFGDKPYLGFEHVTMTPHCRNLVDMSLLTEDEKKFINEYHKEVYEKTSKYFENDALTLEWLKRETAPY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS231615
EMBL· GenBank· DDBJ
EDU40522.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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