B2VL10 · PQQE_ERWT9

Function

function

Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site22[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site26[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site29[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncyclase activity
Molecular Functioniron ion binding
Molecular Functionoxidoreductase activity
Molecular FunctionS-adenosyl-L-methionine binding
Biological Processpyrroloquinoline quinone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    PqqA peptide cyclase
  • EC number
  • Alternative names
    • Coenzyme PQQ synthesis protein E
    • Pyrroloquinoline quinone biosynthesis protein E

Gene names

    • Name
      pqqE
    • Ordered locus names
      ETA_28860

Organism names

Accessions

  • Primary accession
    B2VL10

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001312751-382PqqA peptide cyclase

Interaction

Subunit

Interacts with PqqD. The interaction is necessary for activity of PqqE.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-223Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. PqqE family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    382
  • Mass (Da)
    43,040
  • Last updated
    2008-07-01 v1
  • Checksum
    EAE66910F563AAE6
MNPSESNVKPPLWLLAELTYRCPLQCPYCSNPLDFAQQEKELSTAQWIEVFKQARAMGAVQIGFSGGEPLVRKDLPELIRSARELGFYTNLITSGIGLTQKKIDAFAEAGLDHIQISFQASDETLNAALAGSQKAFQQKLEMARAVKAHGYPMVLNFVLHRHNIDQLDRIIELCIELEADDVELATCQFYGWAQLNREGLLPTRDQLVRAEAVVHRYREKMAASGNLANLLFVTPDYYEERPKGCMGGWGAIFLSVTPEGMALPCHSARQLPIRFPSVLEHSLQDIWFNSFGFNRYRGFDWMPEPCRSCDEKEKDFGGCRCQAFMLTGNADNADPVCSKSEHHGTILAAREQANCTNIQVNQLRFRNRANSERVNSQLIFKG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU468135
EMBL· GenBank· DDBJ
CAO97932.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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