B2V4J4 · RISB_CLOBA

Function

function

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

Catalytic activity

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.

Features

Showing features for binding site, active site.

115320406080100120140
Type
IDPosition(s)Description
Binding site225-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site56-585-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site80-825-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site85-86(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)
Active site88Proton donor
Binding site1135-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site127(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentriboflavin synthase complex
Molecular Function6,7-dimethyl-8-ribityllumazine synthase activity
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6,7-dimethyl-8-ribityllumazine synthase
  • EC number
  • Short names
    DMRL synthase
    ; LS
    ; Lumazine synthase

Gene names

    • Name
      ribH
    • Ordered locus names
      CLH_1249

Organism names

Accessions

  • Primary accession
    B2V4J4

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000981761-1536,7-dimethyl-8-ribityllumazine synthase

Structure

Family & Domains

Sequence similarities

Belongs to the DMRL synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    153
  • Mass (Da)
    16,317
  • Last updated
    2008-07-01 v1
  • MD5 Checksum
    317A4171F39ABFDC6FDA539CCEE4B461
MNIFEGKLIAEGLKVGIIVGRFNEFIGSKLLDGALDGLKRHGVNLEDIDVAWVPGAFEMPLIAKKMAKSPKYDAVICLGAVIKGSTSHYDYVCSEVSKGIANVSLETGKPVMFGVLTTNNIEQAIERAGTKAGNKGYECAVGAIEMANLIKEL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001078
EMBL· GenBank· DDBJ
ACD52594.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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