B2UXD4 · COBQ_CLOBA

Function

function

Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis.

Features

Showing features for active site.

150150100150200250300350400450500
TypeIDPosition(s)Description
Active site332Nucleophile
Active site438

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionABC-type vitamin B12 transporter activity
Molecular Functioncatalytic activity
Biological Processcobalamin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cobyric acid synthase

Gene names

    • Name
      cobQ
    • Ordered locus names
      CLH_2659

Organism names

Accessions

  • Primary accession
    B2UXD4

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000902231-501Cobyric acid synthase

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain251-446GATase cobBQ-type

Sequence similarities

Belongs to the CobB/CobQ family. CobQ subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    501
  • Mass (Da)
    55,803
  • Last updated
    2008-07-01 v1
  • MD5 Checksum
    8E221356E7D9FBD303F4D731EEF3AD4C
MNKKNIMFLGTASSVGKSTLVAALCRVLKNEDFKVSPFKAMNISLNSYVTKDGAEMGRAQVVQAEASKIEPSALMNPILLKPSGGHTQVIVNGKVYDNIEPYEYKELNKKLKGIVKESYDRISNEYDLIVLEGSGGCAEINLKDTDIANMNMAECVDAPVILVADIDRGGVFASIVGTLNLLSENERKRVKGVIINKFRGKKEYFEPGVKQLEDIIKIPVLGVMPYEYFDIDDEDSVTEKISNKESTEAKNIDIAIIRLSHMSNFTDFNVLNRINGVNIRYVESTKYLKNPDVIIIPGTKNTIEDLRILKESKLANEIIKLHESGTLVFGICGGYQMLGKLLLDQQGVEGSTFQEEGLGLLDIKTRFNERKVTKQVEAQVVSNLKHINEIENKSLVGYEIHNGISKVGKNAKPFIKDSKGKIIGVCDMEGSVAGTYLHGIFDSEEFTNSFINALKKNNNFELLENDELDKVSDYKNEQYEKLAKVFSDNIDVSKIKEIMGI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001078
EMBL· GenBank· DDBJ
ACD53442.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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