B2UNH4 · GCSP_AKKM8
- ProteinGlycine dehydrogenase (decarboxylating)
- GenegcvP
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids948 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Catalytic activity
- glycine + H+ + N6-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] = CO2 + N6-[(R)-S8-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein]
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | glycine cleavage complex | |
Molecular Function | glycine binding | |
Molecular Function | glycine dehydrogenase (decarboxylating) activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | glycine decarboxylation via glycine cleavage system |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycine dehydrogenase (decarboxylating)
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Verrucomicrobiota > Verrucomicrobiia > Verrucomicrobiales > Akkermansiaceae > Akkermansia
Accessions
- Primary accessionB2UNH4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000190203 | 1-948 | Glycine dehydrogenase (decarboxylating) | |||
Sequence: MNTHSDFASRHIGPQGEERREMLDSLGYRTLDELIADIVPADIRMKAPLDLPAAKSETEALEELRSILRKNKLLKTFIGQGYYGTITPSVILRNVLENPGWYTAYTPYQPEIAQGRLEMLMNFQTMVSSLTGLPVANASLLDEGTAAAEAVTMCRNARPKANTFFVADTCHPQTISVIRTRAAFQGVNIIVGDCSSFDPASIGADLAGVLVQYPDTLGRICDYTDFFSRVHATGALCVVAADLMALTVIREPGAFGADICIGNTQHFGIPMGFGGPHAAYMSCTDALKRRMPGRLIGMSIDTLGRPAYRLALQTREQHIRRDKATSNICTAQVLLAVLAAFYAVYHGQEGLKRIGTEIHLKTKSLYKALTEAGIAIENKNFFDTLLLSVPGQADAMVQKALEAGYNIRRVDADHAAISLDETATCADIAALASALAGAETSAACDCDAPAWDPVHTRQTPFCTEKAFNSYHSETEMMRYIRRLESRDLALNEAMIPLGSCTMKLNAASEMIPITWPEANSLHPFVPADQSEGIREMLSILSDRLAKITGFAAVSLQPNAGAAGEYAGLLAIRRYQKHAGEGHRNVCLIPTSAHGTNPASSAMAGLKVVPVKCDERGNIDMADLKSQAEAHKDNLSCIMVTYPSTHGVYEQTIKELCDIVHANGGQVYMDGANMNAQVGLTCPGCIGADVCHLNLHKTFAMPHGGGGPGIGPIGVAEHLVPFLPGHLTLGHEEGAVASAAWGSASIAAICWMYLSMMGPDGLREATEMAILNANYIAKKLGHLFPVLYSGNKGLVAHECILDPRQLTHDAGLTVDDIAKRLMDYGFHGPTMSFPVPGTLMVEPTESEPKKELDRFIEAMERIHAEITAIINGTADKEDNVLKNSPHTAEMVSADEWRHPYSRSEAAYPVSGLLIHKFWPYVGRVDNVYGDRNLVCTCDTVEEFSKAVEL | ||||||
Modified residue | 696 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Proteomic databases
Interaction
Subunit
The glycine cleavage system is composed of four proteins: P, T, L and H.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length948
- Mass (Da)102,650
- Last updated2008-07-01 v1
- ChecksumE26EDF5979A4EAF0
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001071 EMBL· GenBank· DDBJ | ACD04286.1 EMBL· GenBank· DDBJ | Genomic DNA |