B2UND0 · PANC_AKKM8
- ProteinPantothenate synthetase
- GenepanC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids281 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Miscellaneous
The reaction proceeds by a bi uni uni bi ping pong mechanism.
Catalytic activity
- (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H+
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 30-37 | ATP (UniProtKB | ChEBI) | ||||
Sequence: MGALHAGH | ||||||
Active site | 37 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 64 | (R)-pantoate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 64 | beta-alanine (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 150-153 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GKKD | ||||||
Binding site | 156 | (R)-pantoate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 179 | ATP (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 187-190 | ATP (UniProtKB | ChEBI) | ||||
Sequence: YSSR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantoate-beta-alanine ligase activity | |
Biological Process | pantothenate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePantothenate synthetase
- EC number
- Short namesPS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Verrucomicrobiota > Verrucomicrobiia > Verrucomicrobiales > Akkermansiaceae > Akkermansia
Accessions
- Primary accessionB2UND0
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000097026 | 1-281 | Pantothenate synthetase | |||
Sequence: MQTFSTKAQLRAALLKHHRKHDHVVLVPTMGALHAGHRALLEQARKLAGEDGVVVASIFVNPIQFNNSSDLQTYPRTPEKDLEVCEGAGVDYVFSPAPEEMYSGERSIAVEESFLSATLCGASRPGHFSGVCTVLAKLFNLVQPTDAIFGKKDYQQLAIIRRMVRDLDFPVRIHGAEIVRHGNGLAYSSRNARLTPEQKEQAVVIRQAMLQARDEFQAGADASKVKEHAAAMIEGVPGTRIDYLEIVDAETMQPVAENRKPALMAAAVYFGDVRLIDNIEL |
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length281
- Mass (Da)30,917
- Last updated2008-07-01 v1
- ChecksumCC39BF5AD725D307
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001071 EMBL· GenBank· DDBJ | ACD04242.1 EMBL· GenBank· DDBJ | Genomic DNA |